2011 Fiscal Year Final Research Report
A STUDY ON ROLES OF POLYMERIC OSTEOPONTIN IN PROGRESSION OF PULMONARY FIBROSIS
Project/Area Number |
21590996
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Hiroshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
MORIMOTO Yasuo 産業医科大学, 産業生態科学研究所, 教授 (30258628)
MATSUDA Haruo 広島大学, 生物圏科学研究科, 教授 (80116863)
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Co-Investigator(Renkei-kenkyūsha) |
YATERA Kazuhiro 産業医科大学, 医学部, 助教 (40341515)
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Project Period (FY) |
2009 – 2011
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Keywords | オステオポンチン / トランスグルタミナーゼ / インテグリン / 肺線維症 / 重合 / 好中球 |
Research Abstract |
Osteopontin(OPN) is involved in pulmonary fibrosis by yet unknown mechanism. We investigated if OPN polymerization leads to pulmonary fibrosis, and found followings. 1) Polymeric OPN is a chemoattractant for neutrophils in vitro, 2) integrinα9β1 recognition site is formed on polymeric OPN upon polymerization, 3) polymeric OPN is also attracts neutrophils in vivo, 4) monomeric OPN, by converting into polymer, also attracts neutrophils in vivo. These results strongly suggest polymerization of OPN can regulate tissue accumulation of neutrophils that could induce fibrosis.
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Research Products
(12 results)
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[Journal Article] Osteopontinis a tumor autoantigen in prostate cancerpatients2011
Author(s)
Tatiana M. Tilli, Eloisio A. Silva, Livia C. Matos, Douglas V. Faget, Bianca F. P. Dias, Juliana S. P. Vasconcelos, Yasuyuki Yokosaki, Etel R. P. Dias, Juliana S. P. Vasconcelos, Yasuyuki Yokosaki, Etel R. P. Gimb
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Journal Title
Oncol lett
Volume: 2
Pages: 109-114
DOI
Peer Reviewed
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