2011 Fiscal Year Final Research Report
Molecular mechanisms and roles of cell senescence in lung injury and repair
| Project/Area Number |
21591004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Katsutoshi 東京慈恵会医科大学, 医学部, 准教授 (40321989)
ARAYA Jun 東京慈恵会医科大学, 医学部, 講師 (90468679)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肺損傷 / 細胞老化 / アポトーシス / 特発性肺線維症 |
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| Research Abstract |
We found bronchial and alveolar epithelial cell senescence in lung tissues from patients with idiopathic pulmonary fibrosis(IPF), but not fibroblast senescence. These results suggest that the difference of responsiveness to microenvironment in each type of cells leads to tissue remodeling and pulmonary fibrosis. TGF-beta induced cell senescence in human primary cultured bronchial epithelial cells and SIRT6 inhibited it. To inhibit epithelial cell senescence may leads to prevent pulmonary fibrosis.
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[Journal Article] Insufficient autophagic clearance promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.2012
Author(s)
Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Kawaishi M, Kamiya K, Hirano J, Odaka M, Morikawa T, Stephen L Nishimura S, Nakayama K, Kuwano K
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Journal Title
Oncoimmunology
Volume: (in press)
Peer Reviewed
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[Journal Article] Involvement of creatine kinase B in cigarette smoke induced-bronchial epithelial cell senescence2012
Author(s)
Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K
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Journal Title
Am J Respir Cell Mol Biol
Volume: 46
Pages: 306-312
Peer Reviewed
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[Journal Article] Insulin Dependent Phosphatidylinositol 3-Kinase/Akt and ERK Signaling Pathways Inhibit TLR3-Mediated Human Bronchial Epithelial Cell Apoptosis2011
Author(s)
Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
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Journal Title
J Immunol
Volume: 187
Pages: 510-9
Peer Reviewed
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[Journal Article] Accelerated Epithelial Cell Senescence in IPF and the Inhibitory Role of SIRT6 in TGF-{beta}-induced Senescence of Human Bronchial Epithelial Cells2011
Author(s)
Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 300
Pages: L391-L401
Peer Reviewed
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