• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

The effects of fatty acid emulsion for cisplatin-induced acute renal failure in rats

Research Project

  • PDF
Project/Area Number 21591015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionHirosaki University

Principal Investigator

NAKAMURA Norio  弘前大学, 大学院・医学研究科, 准教授 (60332657)

Project Period (FY) 2009 – 2011
Keywords腎臓学
Research Abstract

In this study, we created an infusible emulsion of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and investigated the effect of the emulsion against cisplatin-induced acute renal failure model of rats. However, there were no beneficial effect of the emulsion in the model. We also investigated the effect of DHA emulsion against nephrotoxic serum nephritis model of rats. After the administration of the emulsion, the levels of protein excretion of urine were decreased in the rats. These results suggest that DHA emulsion might be beneficial effects for the renal disease.

  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Effects of tridocosahexaenoyl-glycerol emulsion on proteinuria in rats with nephrotoxic serum nephritis2011

    • Author(s)
      Nakamura N, Kumasaka R, Y-F Lu, Fujita T, Murakami R, Shimada M, Shimaya Y, Osawa H, Yamabe H, Okumura K, Hamazaki K, Hamazaki T
    • Journal Title

      Nephron Extra

      Volume: 1 Pages: 139-146

    • DOI

      DOI:10.1159/000333479

    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task2011

    • Author(s)
      Hamazaki-Fujita N, Hamazaki K, Tohno H, Itomura M, Terashima Y, Hamazaki T, Nakamura N, Yomoda S
    • Journal Title

      Brain Res

      Volume: 1397 Pages: 38-45

    • Peer Reviewed
  • [Journal Article] Clinicopathological study on hepatitis C virus-associated glomerulonephritis without hepatits C virus in the blood2010

    • Author(s)
      Yamabe H, Nakamura N, Shimada M, Murakami R, Fujita T, Shimaya Y, Kitajima M, Urushizaka M
    • Journal Title

      Intern Med

      Volume: 49 Pages: 1321-1323

    • Peer Reviewed
  • [Journal Article] Complications after surgery in hemodialysis patients : A comparison between diabetic and non-diabetic patients2009

    • Author(s)
      Shimoyama Y, Nakamura N, Kawaguchi T, Okumura K
    • Journal Title

      Dialysis & Transplantation

      Volume: 38 Pages: 412-414

    • Peer Reviewed
  • [Journal Article] Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney2009

    • Author(s)
      Shimada M, Yamabe H, Osawa H, Nakamura N, Kumasaka R, Murakami R, Fujita T, Osanai T, Okumura K
    • Journal Title

      Nephrology

      Volume: 14(2) Pages: 171-178

    • Peer Reviewed
  • [Journal Article] CKD患者の輸液と経腸栄養の指針-ステージ4・5患者への対策.III脂肪酸輸液の指針2009

    • Author(s)
      中村典雄
    • Journal Title

      臨床透析

      Volume: 25(13) Pages: 1795-1800

  • [Presentation] Thrombin stimulates synthethis of GM-CSF, G-CSF, M-CSF, MCP-1 and IL-8 in human proximal tubular epithelial cells in culture2011

    • Author(s)
      Shimada M, Shimaya Y, Yamabe H, Fujita T, Murakami R, Nakamura N, Okumura K
    • Organizer
      World Congress of Nephrology 2011
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20110408-12
  • [Presentation] Mizoribine (MZR) suppresses proliferation of rat glomerular epithelial cells (GEC) in culture and attenuates the expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) augmentes by thrombin2011

    • Author(s)
      Yamabe H, Shimada M, Murakami R, Fujita T, Shimaya Y, Nakamura N, Okumura K
    • Organizer
      World Congress of Nephrology 2011
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20110408-12
  • [Presentation] Patholigical findings by electron microscopy in hepatitis C virus-associated glomerulonephritis2010

    • Author(s)
      Yamabe H, Nakamura N, Shimada M, Murakami R, Fujita T, Shimaya Y, Okumura K, Kaizuka M
    • Organizer
      The 12th Asian Pacific Congress of Nephrology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20100605-08

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi