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2011 Fiscal Year Final Research Report

Investigation for anti-renal fibrotic effects of lipid-binding proteins and lipid-activated nuclear receptors and search for new therapeutic reagents

Research Project

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Project/Area Number 21591024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Fukui

Principal Investigator

KIMURA Hideki  福井大学, 医学部, 准教授 (20283187)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Haruyoshi  福井大学, 医学部, 教授 (80135574)
KASUNO Kenji  福井大学, 医学部, 助教 (60455243)
SUGAYA Takeshi  聖マリアンナ医科大学, 医学部, 客員教授 (40381561)
Project Period (FY) 2009 – 2011
Keywords腎臓学 / ペルオキシゾーム増殖剤応答性受容体 / 脂肪酸結合蛋白 / 尿細管上皮細胞 / メサンギウム細胞 / 炎症 / アンジテンシンII受容体拮抗薬
Research Abstract

Presence and activities of peroxisome proliferator-activated receptor(PPAR)-δandγwere confirmed in human proximal renal tubular epithelial cells and mesangial cells which inflammatory insults targeted mainly during progression of renal injury. An angiotensin II receptor blocker, telmisartan was shown to have PPAR-δandγ-induced transcriptional activities and increase expression of their target genes such as fatty acid-binding protein(FABP) and liver X receptor. Telmisartan also decreased gene expression of monocyte chemoattractant protein-1(MCP-1). In the mouse immortalized proximal renal tubular cell line with over-expression of human liver-type FABP, a putative transporter of PPAR ligands, mouse PPAR-δwas up-regulated and MCP-1 down-regulated. These results suggest that some bioactive molecules with a potential to affect function and dynamism of PPAR and FABP are candidates of new therapeutic reagents for chronic kidney disease.

  • Research Products

    (12 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient2012

    • Author(s)
      Takahashi N, Kimura H
    • Journal Title

      Clin Exp Nephrol

      Volume: 7

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/2484642

    • Peer Reviewed
  • [Journal Article] Smaller low-density lipoprotein size as a possible risk factor for the prevalence of coronary artery diseases in haemodialysis patients2011

    • Author(s)
      Kimura H, Miyazaki R
    • Journal Title

      Nephrology

      Volume: 16 Pages: 558-566

    • DOI

      DOI:11/j.1440-1797.2011.01454.x

    • Peer Reviewed
  • [Journal Article] Glucocorticoid enhances hypoxia-and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells2011

    • Author(s)
      Kimura H, Li X
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Pages: 34-40

    • DOI

      DOI:07/s10157-010-0351-7

    • Peer Reviewed
  • [Journal Article] Clinical application of urinary redox regulating protein, thioredoxin.2011

    • Author(s)
      Kasuno K, Kimura H
    • Journal Title

      J J Clin Pathol

      Volume: 59 Pages: 189-195

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/1476306

  • [Journal Article] Tubulointerstitial nephritis with IgM-positive plasmacytoid large lymphocyte infiltration in a patient with primary biliary cirrhosis and Sjogren's syndrome2010

    • Author(s)
      Takahashi N, Kimura H
    • Journal Title

      Clin Nephrol

      Volume: 74 Pages: 74-80

    • DOI

      DOI:5414/CNP74074

    • Peer Reviewed
  • [Journal Article] Acute on chronic subdural hematoma as a rare complication in a microscopic polyangiitis patient receiving antithrombotic treatment2009

    • Author(s)
      Takahashi N, Kimura H
    • Journal Title

      Clin Nephrol

      Volume: 72 Pages: 211-215

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19761727

    • Peer Reviewed
  • [Journal Article] Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells2009

    • Author(s)
      Kimura H, Li X, Torii K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 24 Pages: 1759-1765

    • DOI

      DOI:10.1093/ndt/gfn756

    • Peer Reviewed
  • [Presentation] Overexpression of Human Liver-Fatty Acid-Binding Protein endogenously Enhances Peroxisome Proliferator Activated Receptor-αActivity possibly via inducing Hepatocyte Nuclear Factor-4αin Immortalized Mouse Proximal Renal Tubular Cells2011

    • Author(s)
      Kimura H
    • Organizer
      The annual meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Year and Date
      20111108-13
  • [Presentation] Discrete Regulation of VEGF-A and-C in Human Proximal Renal Tubular Cells under Hypoxic and/or Inflammatory Conditions. Inhibitory Effects of Glucocorticoids on Basal and Inducible VEGF Expression2010

    • Author(s)
      Kimura H
    • Organizer
      The annual meeting of American Society of Nephrology
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      20101116-21
  • [Presentation] LDL size reduction as a possible risk factor for the prevalence of coronary artery diseases in hemodialysis patients2010

    • Author(s)
      Kimura H
    • Organizer
      The annual meeting of American Society of Nephrology
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      20101116-21
  • [Presentation] Acceleration of diabetic glomerulopathy in db/db mice in chronic hypoxia2010

    • Author(s)
      Kimura H
    • Organizer
      The annual meeting of American Society of Nephrology
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      20101116-21
  • [Presentation] Uninary thioredoxin is a quick and predictive biomarker of acute kidney injury2010

    • Author(s)
      Kasuno K, Kimura H
    • Organizer
      The annual meeting of American Society of Nephrology
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      20101116-21

URL: 

Published: 2013-07-31  

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