2011 Fiscal Year Final Research Report
A comprehensive analysis of serine proteases involved in the renal injury induced by aldosterone and salt loading
| Project/Area Number |
21591035
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMITA Kimio 熊本大学, 大学院・生命科学研究部, 教授 (40114772)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 腎臓学 |
|---|
| Research Abstract |
Aldosterone has been demonstrated to induce severe organ damage to animals when administered with high salt diet. We demonstrated that a serine protease inhibitor significantly reduced the progression of renal injury induced by aldosterone and high salt diet, suggesting that serine proteases are involved in the development of renal injury. We isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.
|
