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2011 Fiscal Year Final Research Report

Protective role of FSP1-positive podocytes in the glomerular injury

Research Project

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Project/Area Number 21591036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Fukui (2011)
Nara Medical University (2009-2010)

Principal Investigator

IWANO Masayuki  福井大学, 医学部, 教授 (20275324)

Co-Investigator(Kenkyū-buntansha) KUBO Atsushi  奈良県立医科大学, 医学部, 助教 (30316062)
Project Period (FY) 2009 – 2011
Keywordsポドサイト / FSP1 / 糸球体保護 / アポトーシス / バイオマーカー
Research Abstract

The number of FSP1-positive podocytes was elevated in active glomerular damage, especially in crescentic glomerulonephritis(GN). Patients with crescentic GN exhibited elevated levels of urinary FSP1, suggesting the potential use of urinary FSP1 to screen for active and ongoing glomerular damage, such as the formation of cellular crescents. To investigate the role of FSP1-positive podocytes, we generated various kinds of experimental nephritis using FSP1 transgenic mice and FSP1 knockout mice. However, we cannot confirm the protective role of FSP1-positive podocytes in these models.

  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (2 results)

  • [Journal Article] Decreased renalα-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012

    • Author(s)
      Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
    • Journal Title

      Kidney Int

      Volume: 81(6) Pages: 539-47

    • DOI

      DOI:10.1038/ki.2011.423

    • Peer Reviewed
  • [Journal Article] Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis2012

    • Author(s)
      Samejima K, Nakatani K, Suzuki D, Asai O, Sakan H, Yoshimoto S, Yamaguchi Y, Matsui M, Akai Y, Toyoda M, Iwano M, Saito Y
    • Journal Title

      Nephron Clin Pract

      Volume: 120(1) Pages: c1-7

    • DOI

      DOI:10.1159/000334184

    • Peer Reviewed
  • [Journal Article] Urinary FSP1 is a biomarker of crescentic GN2012

    • Author(s)
      Iwano M, Yamaguchi Y, Iwamoto T, Nakatani K, Matsui M, Kubo A, Akai Y, Mori T, Saito Y
    • Journal Title

      J Am Soc Nephrol

      Volume: 23(2) Pages: 209-14

    • DOI

      DOI:10.1681/ASN.2011030229

    • Peer Reviewed
  • [Journal Article] Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population2011

    • Author(s)
      Kubo A, Stull R, Takeuchi M, Bonham K, Gouon-Evans V, Sho M, Iwano M, Saito Y, Keller G, Snodgrass R
    • Journal Title

      PLoS One

      Volume: 6(9) Pages: e24058

    • DOI

      DOI:10.1371/journal.pone.0024058

    • Peer Reviewed
  • [Journal Article] Fractalkine expression and CD16+monocyte accumulation in glomerular lesions : association with their severity and diversity in lupus models2010

    • Author(s)
      Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Hasegawa H, Nose M, Saito Y
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299(1) Pages: F207-16

    • DOI

      DOI:10.1152/ajprenal.00482.2009

    • Peer Reviewed
  • [Journal Article] The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm2010

    • Author(s)
      Kubo A, Kim YH, Irion S, Kasuda S, Takeuchi M, Ohashi K, Iwano M, Dohi Y, Saito Y, Snodgrass R, Keller G
    • Journal Title

      Hepatology

      Volume: 51(2) Pages: 633-41

    • DOI

      DOI:10.1002/hep.23293

    • Peer Reviewed
  • [Journal Article] EMT and TGF-beta in renal fibrosis2010

    • Author(s)
      Iwano M
    • Journal Title

      Front Biosci(Schol Ed)

      Volume: 2 Pages: 229-38

    • Peer Reviewed
  • [Journal Article] Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis2009

    • Author(s)
      Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, Nakajima T, Akai Y, Iwano M, Saito Y
    • Journal Title

      Circulation

      Volume: 120(24) Pages: 2470-7

    • DOI

      DOI:10.1161/CIRCULATIONAHA.109.867929

    • Peer Reviewed
  • [Journal Article] Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy2009

    • Author(s)
      Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, Harada K, Kubo A, Akai Y, Toyoda M, Kanauchi M, Neilson EG, Saito Y
    • Journal Title

      Am J Kidney Dis

      Volume: 54(4) Pages: 653-64

    • DOI

      DOI:10.1053/j.ajkd.2009.05.009

    • Peer Reviewed
  • [Presentation] 半月体病変判定における尿中FSP1の臨床的意義2011

    • Author(s)
      岩野正之, 他
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-15
  • [Presentation] 尿中FSP1測定法の確立と臨床的意義2009

    • Author(s)
      岩野正之, 他
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-05

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Published: 2013-07-31  

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