2011 Fiscal Year Final Research Report
The role of neutral calponin in the relationship between CKD and CVD
| Project/Area Number |
21591041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | CKD / CVD / カルポニン / 線維化 |
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| Research Abstract |
I examined the role of neutral calponin(nCT) in the interstitial injury of both kidneys and heart in old nCT-transgenic mice. for studying the mechanism for cardio-renal association in CKD. Old nCT-Tg mice showed suppression of interstitial inflammation in the kidney and of the development of interstitial fibrosis in both heart and kidneys. Therefore, the induction of nCT may provide a new way to suppress the development of both CKD and CVD23 in old-age CKD patients.
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