Intermittent hypoxia in the progression of diabetic nephropathy and Intermittent hypoxia in the progression of diabetic nephropathy and Role of fatty acid binding protein

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: KIMURA Kenjiro 聖マリアンナ医科大学, 医学部, 教授 (00161555)
• Co-Investigator(Kenkyū-buntansha): SUGAYA Takeshi 聖マリアンナ医科大学, 医学部, 客員教授 (40381561) ; IKEMORI Atsuko 聖マリアンナ医科大学, 医学部, 講師 (80350635)
• Project Period (FY): 2009 – 2011
• Keywords: 間欠的低酸素 / 虚血ストレス / 脂肪酸結合蛋白 / 低酸素 / 高血圧 / 糖尿病

Research Abstract

Because sleep apnea syndrome(SAS) may contribute to poor control of diabetes or hypertension, it is possible that SAS is a risk factor for the progression of diabetic nephropathy. In this study, genetic models of type 1 diabetes or hypertension model were examined. The mice or rats were housed within a cycled oxygen chamber and were exposed to chronic intermittent hypoxia(CIH) in which oxygen and nitrogen flow rates were adjusted to achieve episodic(10 miniute) reductions of ambient oxygen from 21% to 10% for CIH for 12 hours. Howerver, it was not demonstrated that chronic intermittent hypoxia was related to the deterioration of kidney disease induced by diabetes or hypertension.