2011 Fiscal Year Final Research Report
Anti-fibrotic effects of klotho through the inhibition of Wnt signaling
| Project/Area Number |
21591046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIHARA Naoki 川崎医科大学, 医学部, 教授 (10233701)
MORITA Yoshitaka 川崎医科大学, 医学部, 講師 (50346441)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腎臓学 |
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| Research Abstract |
The kidney increases fibrotic changes with aging and gradually progresses to chronic renal failure. The Klotho protein secreted by kidney attenuates fibrosis, progress to renal dysfunction by inhibiting Wnt signal promoting fibrosis. Organ fibrotic changes progresses as well as kidney with aging and leads to organ functional decline with aging. But Klotho may restrain fibrosis of not only the kidney but also the other organs and may work for anti-aging. To keep the renal function normally may lead to the prevention of the aging.
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