2011 Fiscal Year Final Research Report
Analysis of T cell differentiation in IgG4 related kidney disease
| Project/Area Number |
21591048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Katsuhisa 福岡大学, 医学部, 講師 (50448411)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腎臓病 |
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| Research Abstract |
We selected twenty cases of histologically diagnosed as tubulointerstitial nephritis(TIN). These cases were etiologically different and included four cases of IgG4-related TIN. We extracted RNA from paraffin embedded biopsied kidney, and evaluated expression levels of various cytokines for each case by real time PCR. Comparison of cytokine production patterns among different disease associated TINs revealed that IgG4-related TIN exhibited a quite distinct pattern. On one hand there was no expression of IL-2, IFN-γ, IL-17 and IL-6, whereas productions of IL-4, IL-10 and TGF-β were remarkably increased in IgG4-related TIN. Based on these cytokine production results, Th2 and Treg appears to play a central role in IgG4-related TIN.
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[Journal Article] Proposal for diagnostic criteria for IgG4-related kidney disease2011
Author(s)
Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, Yamanaka N, Inoue D, Yamamoto M, Takahashi H, Nomura H, Taguchi, Umehara H, Makino H, Saito T
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Journal Title
Clin Exp Nephrol
Volume: 15
Pages: 615-26
Peer Reviewed
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[Journal Article] Amelioration of diabetic nephropathy in OLETF rats by Prostaglandin I_2 analog, beraprost sodium2009
Author(s)
Watanabe M, Nakashima H, Mochizuki S, Abe Y, Ishimura A, Ito K, Fukushima K, Miyake K, Ogahara S, Saito T
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Journal Title
Am J Nephrol
Volume: 30
Pages: 1-11
Peer Reviewed
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