Complement-associated analysis for improvement of prognosis in patients on long-term peritoneal dialysis

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: MIZUNO Masashi 名古屋大学, 大学院・医学系研究科, 講座講師 (20303638)
• Co-Investigator(Kenkyū-buntansha): ITO Yasuhiko 名古屋大学, 大学院・医学系研究科, 講座教授 (60402632) ; 松尾 清一 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
• Project Period (FY): 2009 – 2011
• Keywords: 人工透析学 / 腹膜透析 / 慢性腹膜炎症 / 腹膜硬化症 / 補体 / 抗補体治療

Research Abstract

We showed that membrane complement(C) regulators(CRegs) played key roles in normal rat peritoneum and that low pH and high osmotic pressure as elements of peritoneal dialysis(PD) fluid increased peritoneal injuries under functional blocking of CRegs. We also showed that CRegs' impairments might accelerate peritoneal injuries to encapsulating peritoneal sclerosis in the zymosan induced peritonitis model in rats.

Research Products

• [Journal Article] Me mbrane complement regulators protect against fibrin-exudation, an early stage of encapsulating peritoneal sclerosis(EPS) (2012)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Suzuki Y, Harris CL, Okada N, Matsuo S, Morgan BP.
  • Journal Title: Am J Physiol Renal Physiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Transforming growth factor-υin duce vascular endo the lial growth factor-C expressio nleading to lymph angiogenesis in rat unilateral ureteral obstruction. (2012)
  • Author(s): Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y.
  • Journal Title: Kidney Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Low serum cultured a dipose tissue-derived stromal cells a meliorate acute kidney injury in rats (2012)
  • Author(s): Katsuno T, Osaki T, Saka Y, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama S.
  • Journal Title: Cell Transplant Volume: (in press)
  • Peer Reviewed
• [Journal Article] Asympto maticdiver ticulosis identified by computed tomography is not a risk factor for enteric peritonitis (2012)
  • Author(s): Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.
  • Journal Title: Nephrol Dial Tranplant Volume: (in press)
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model (2012)
  • Author(s): Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.
  • Journal Title: Nephrol. Dial. Transplant Volume: 27 Pages: 526-536
  • Peer Reviewed
• [Journal Article] Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis (2012)
  • Author(s): Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.
  • Journal Title: Perit Dial Int Volume: 32 Pages: 111-113
  • Peer Reviewed
• [Journal Article] Renal impairment after laparoscopic radical nephrectomy affects hypoglycemic therapy (2012)
  • Author(s): Mizuno T, Ito K, Miyagawa Y, Kimura K, Suzuki K, Mizuno M, Ito Y, Funabashi Y, Hattori R, Gotoh M, Noda Y, Yamada K.
  • Journal Title: J. Clin Pharm Therapy Volume: 37 Pages: 49-52
  • Peer Reviewed
• [Journal Article] Peritonitis is still an important factor for withdrawal from peritoneal dialysis the rapy in the Tokai area of Japan (2011)
  • Author(s): Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, MatsuokaT, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 727-737
  • Peer Reviewed
• [Journal Article] A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis (2011)
  • Author(s): Suzuki Y, Mizuno M, Nakashima R, Hiramatsu H, Toda S, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S, Ito Y.
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 962-965
  • Peer Reviewed
• [Journal Article] A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.
  • Journal Title: Intern Med Volume: 50 Pages: 471-474
  • Peer Reviewed
• [Journal Article] A case of acute renal failure caused by cholesterol embolization after carotid artery tenting that was improved by peritoneal dialysis (2011)
  • Author(s): Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Tatematsu M, Ozaki T, Sato W, Tsuboi N, Ito I, Marumaya S, Imai E, Matsuo S.
  • Journal Title: Intern Med Volume: 50 Pages: 1719-1723
  • Peer Reviewed
• [Journal Article] An update on the roles of the complement system in autoimmune diseases and the therapeutic possibilities of anti-complement agents (2011)
  • Author(s): Mizuno M, Morgan BP.
  • Journal Title: Current Drug Therapy Volume: 6 Pages: 35-50
  • Peer Reviewed
• [Journal Article] Specific collaboration between rat membrane complement regulators Crry and CD 59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid (2011)
  • Author(s): Mizuno T, Mizuno M, Okada N, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y.
  • Journal Title: Nephrol. Dial. Transplant Volume: 26 Pages: 1821-1830
  • Peer Reviewed
• [Journal Article] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients (2011)
  • Author(s): Sawai A, Ito Y, Mizuno M, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S.
  • Journal Title: Nephrol. Dial. Transplant Volume: 26 Pages: 2322-2332
  • Peer Reviewed
• [Journal Article] 腹膜透析にかかわる腹膜組織障害における補体の関与 (2011)
  • Author(s): 水野正司、伊藤恭彦、松尾清一
  • Journal Title: 医学のあゆみ Volume: Vol.239 Pages: 779-783
  • Peer Reviewed
• [Journal Article] 残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響 (2011)
  • Author(s): 柴田佳菜子、伊藤恭彦、水野正司、鈴木康弘、平松英樹、伊藤功、戸田晋、丸山彰一、松尾清一
  • Journal Title: 日本透析医学会雑誌 Volume: Vol.44 Pages: 1007-1013
  • Peer Reviewed
• [Journal Article] Connecting tissue growth factor(CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate (2010)
  • Author(s): Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldshmeding R, Aten J, Krediet R, Yuzawa Y, Matsuo S.
  • Journal Title: Am. J. Physiol. Renal Physiol Volume: 298 Pages: F721-F733
  • Peer Reviewed
• [Journal Article] Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient (2010)
  • Author(s): Yuzawa Y, Ito Y, Mizuno M, Sawai A, Matsuo S.
  • Journal Title: Nephrol Dial. Transplant. Plus Volume: 3 Pages: 372-375
  • Peer Reviewed
• [Journal Article] Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia (2010)
  • Author(s): Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S.
  • Journal Title: Inter Med Volume: 49 Pages: 1139-1142
  • Peer Reviewed
• [Journal Article] IX.免疫学的検査C.補体および関連物質 (2010)
  • Author(s): 水野正司、松尾清一
  • Journal Title: 日本臨床 Volume: Vol.68 Pages: 49-52
  • Peer Reviewed
• [Journal Article] 名大腎不全システム研究会レジストリによる東海地区13施設の3年間(2005～2007)解析から得た、現在の腹膜透析療法の傾向と問題点 (2010)
  • Author(s): 水野正司、伊藤恭彦、田中章郎、平松英樹、渡辺緑子、稲熊大城、戸田晋、檀原敦、玉井宏史、倉田久嗣、春日弘毅、志水英明、松岡哲平、鶴田吉和、堀江正宣、成瀬友彦、平松武幸、伊藤功、丸山彰一、湯澤由紀夫、松尾清一
  • Journal Title: 腎と透析2010 Volume: Vol.69 Pages: 638-640
  • Peer Reviewed
• [Journal Article] 基礎カンファレンス腹膜線維化に関する基礎研究の進歩、腹膜線維症・機能不全と成長因子 (2010)
  • Author(s): 伊藤恭彦、水野正司、水谷真、西村勇人、鈴木康弘、澤井晶穂、鬼無洋、湯澤由紀夫、松尾清一
  • Journal Title: 腎と透析2010 Volume: Vol.69 Pages: 128-131
  • Peer Reviewed
• [Journal Article] Lymphatic vessels develop during tubulo-interstitial fibrosis (2009)
  • Author(s): Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.
  • Journal Title: Kidney Int Volume: 75 Pages: 828-838
  • Peer Reviewed
• [Journal Article] Zymosan, but not LPS, developed severe and progressive peritoneal injuries accompanied with complement activation in peritoneal dialysate fluid in a rat peritonitis model with mechanical scraping (2009)
  • Author(s): Mizuno M, Ito Y, Mizuno T, Harris CL, Morgan BP, Hepburn N, Noda Y, Yuzawa Y, Matsuo S.
  • Journal Title: J. Immunol Volume: 183 Pages: 1403-1412
  • Peer Reviewed
• [Journal Article] Tissue-type plasmiogen activator deficiency attenuates peritoneal fibrosis in mice (2009)
  • Author(s): Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.
  • Journal Title: Am. J. Physiol. Renal Physiol Volume: 297 Pages: F1510-F1517
  • Peer Reviewed
• [Presentation] Lymphangiogenesis Developsduring Tubulo-lnterstitial Fibrosis Via theTGF-B-VEGF-C Pathway in Rat UnilateralUreteral Obstruction (2011)
  • Author(s): Suzuki Y, et al.
  • Organizer: ASN Renal Week 2010
  • Place of Presentation: Denver, USA
  • Year and Date: 20111116-21
• [Presentation] Low Serum Cultured Adipose Derived Stem Cells Ameliorate Zymosan Induced Severe Rat Perito nitis Model (2011)
  • Author(s): Kim H, Mizuno M, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20111108-13
• [Presentation] Lymph angiogenesis Developsduring Peritoneal Fibrosis in Peritoneal Dialysis Patients and Rat Peritonitis Model (2011)
  • Author(s): Kinashi H, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20111108-13
• [Presentation] Association of Cardiac Valve Calcification and C-Reactive Protein(CRP) with Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients (2011)
  • Author(s): Ito Y, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20111108-13
• [Presentation] Evaluation of Diverticular Diseases by Computed Tomography Is Useful for Selection of Peritoneal Dialysis Modality and Asympto matic Diverticulosis Is Not a Risk Factor for Peritonitis (2011)
  • Author(s): Ito Y, et al.
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20111108-13
• [Presentation] 腹膜透析に関わる組織障害への補体関与の解析と、腹膜障害に対する抗補体療法の可能性 (2011)
  • Author(s): 水野正司
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20110902-03
• [Presentation] 腹膜擦過にZymosan投与により誘導される高度のラット腹膜炎症モデルにおける、低血清培養による脂肪間葉系幹細胞(LASC)の有用性 (2011)
  • Author(s): 金恒秀、水野正司, 他
  • Organizer: 第48回補体シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20110902-03
• [Presentation] Non-phy siologicalo smolarity and pH in peritoneal dialysis fluid impair comple ment regulation in rat peritoneal mesothelial cells (2011)
  • Author(s): Mizuno M, et al.
  • Organizer: 13^<th> European Complement in Human disease
  • Place of Presentation: Leiden, Holland
  • Year and Date: 20110821-24
• [Presentation] ラット腹膜における膜補体制御因子の役割と腹膜透析の与える影響 (2011)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第56回日本透析医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110617-19
• [Presentation] Zymosan triggers severe and long-term peritoneal injury accompanied by complement activation in a rat peritonitis modelby physical scraping (2011)
  • Author(s): Mizuno M, et al.
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20110512-14
• [Presentation] Peritoneal macrophage in filtration is the predictor of baseline peritonealsolute transport rate in peritoneal dialysis(PD) patients (2011)
  • Author(s): Ito Y, et al.
  • Organizer: 7^<th> International congress on uremia research and toxicity
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20110512-14
• [Presentation] Pertoneal Ma crophage lnfiltration Is Correlated with Baseline Peritoneal Solute Transport Rare Peritoneal Dialysis Patients (2010)
  • Author(s): Sawai A, et al.
  • Organizer: ASN Renal Week 2010
  • Place of Presentation: Denver, USA
  • Year and Date: 20101116-21
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割と腹膜透析液暴露による補体活性系への影響 (2010)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: 大分
  • Year and Date: 20101106-07
• [Presentation] Zymosanによる増殖性腹膜炎モデルの作成と補体の関与 (2010)
  • Author(s): 水野正司, 他
  • Organizer: 第16回日本腹膜透析学会・総会
  • Place of Presentation: 大分
  • Year and Date: 20101106-07
• [Presentation] Thrombotic angiopathyと補体 (2010)
  • Author(s): 水野正司
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島
  • Year and Date: 20100910-11
• [Presentation] 正常ラット腹膜における膜補体制御因子の機能的役割 (2010)
  • Author(s): 水野智博、水野正司, 他
  • Organizer: 第47回補体シンポジウム
  • Place of Presentation: 福島
  • Year and Date: 20100910-11
• [Presentation] Membrane complement regulators may protect against encapsularperitoneal sclerosis(EPS) in a chronic prolife rative in flammation model of zymosan peritonitis in the rat (2010)
  • Author(s): Mizuno M, et al.
  • Organizer: XXII Inter nationalco mplement workshop
  • Place of Presentation: New York, USA
  • Year and Date: 20100801-05
• [Presentation] Zymosan(Z)による増殖性腹膜炎モデルの作成と補体治療の可能性 (2010)
  • Author(s): 水野正司, 他
  • Organizer: 第55回日透析医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 20100618-20
• [Presentation] 腹膜局所炎症は導入初期腹膜透過性と相関する (2010)
  • Author(s): 澤井晶穂, 他
  • Organizer: 第53回日本腎臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 20100616-18
• [Presentation] Lym plangio genesis develop sduring tubulo-interstitial fibrosis in rat unilateral urethral obstruction via TGF-β-BEGF-C pathway (2010)
  • Author(s): Suzuki Y, et al.
  • Organizer: ISN NEXUS
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100415-18
• [Presentation] 名大腎不全システム研究会レジストリー、東海地区13施設の3年間(2005～2007)解析から得た、腹膜透析療法の傾向と問題点 (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第15回日本腹膜透析研究会総会・学術集会
  • Place of Presentation: 静岡
  • Year and Date: 20091128-29
• [Presentation] Connective tissue growth factor(CCN2/CTGF) is increased in peritoneal dialysispatents with high peritoneal solute transport rate (2009)
  • Author(s): Ito Y, et al.
  • Organizer: The 9th European Peritoneal Dialysis Meeting
  • Place of Presentation: Strasbourg, France
  • Year and Date: 20091009-13
• [Presentation] Peritoneal local inflammation is correlated with the baseline peritoneal solute transport rate in peritoneal dialysis patients (2009)
  • Author(s): Sawai A, et al.
  • Organizer: The 9th European Peritoneal Dialysis Meeting
  • Place of Presentation: Strasbourg, France
  • Year and Date: 20091009-13
• [Presentation] Specific collaboration between rat membrane complemen tregulators Crry and CD59 protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid (2009)
  • Author(s): Mizuno T, Mizuno M, et al.
  • Organizer: 12^<th> European Meeting on Complement in Human Diseases
  • Place of Presentation: Visegrad, Hungary
  • Year and Date: 20090905-08
• [Presentation] Zymosanによる増殖性腹膜炎ラットモデルの作成と補体治療の可能性 (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第46回補体シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20090821-22
• [Presentation] 名大腎不全システム研究会レジストリー解析から得た (2009)
  • Author(s): 水野正司, 他
  • Organizer: 第53回日本透析医学会学術集会・総会
  • Place of Presentation: 横浜
  • Year and Date: 20090605-07
• [Book] 7-4.血液透析と補体、編集大井洋之、木下タロウ、松下操、補体学への招 (2011)
  • Author(s): 水野正司
  • Total Pages: 177-183
  • Publisher: メジカルビュー社
• [Book] 8-1.腎尿細管間質障害とと補体、編集大井洋之、木下タロウ、松下操、補体学への招待 (2011)
  • Author(s): 水野正司, 他
  • Total Pages: 210-214
  • Publisher: メジカルビュー社
• [Book] 2. CKDの診断4)腎不全合併症の検索、編集松尾清一、インフォームドコンセントのための図説シリーズ慢性腎臓病(CKD) (2010)
  • Author(s): 水野正司
  • Total Pages: 34-35
  • Publisher: 医薬ジャーナル社