Development of therapies targeting pathogenic oligomers in lipid rafts

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591069
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Hirosaki University
• Principal Investigator: KAWARABAYASHI Takeshi 弘前大学, 医学部・附属病院, 講師 (90186156)
• Co-Investigator(Kenkyū-buntansha): SHOJI Mikio 弘前大学, 大学院・医学研究科, 教授 (60171021)
• Project Period (FY): 2009 – 2011
• Keywords: 神経分子病態学 / リピドラフト / タウ / シヌクレイン

Research Abstract

Lipid rafts are crucial modulators of amyloid ss protein (Aβ) production and aggregation, leading to the accumulation of neurotoxic Aβ oligomers in the brain. Recent findings suggest that lipid rafts are pathological signaling platforms where Aβ oligomers exert synaptic failure and neurotoxicity. Thus lipid rafts are attracted as the target for therapy of Alzheimer's disease (AD). In other neurodegenerative diseases, lipid rafts are also thought to be sites for aggregation and neurotoxicity.

Research Products

• [Journal Article] Sortilin is required for toxic action of Aβ oligomers (AβOs) : Extracellular AβOs trigger apoptosis,and intraneuronal AβOs impair degradation pathways (2012)
  • Author(s): Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E
  • Journal Title: Life Sci
  • Peer Reviewed
• [Journal Article] Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease : Clinical molecular and genetic studies on Alzheimer's disease (2012)
  • Author(s): Shoji M
  • Journal Title: J Pharmacol Sci Volume: 118 Pages: 345-349
• [Journal Article] the Japanese Alzheimer's Disease Neuroimaging Initiative. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease (2012)
  • Author(s): Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, Nagaike K, Ihara Y
  • Journal Title: EMBO Mol Med Volume: 4 Pages: 344-352
  • Peer Reviewed
• [Journal Article] 認知症と臨床検査認知症の病態 (2012)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 臨床検査 Volume: 56 Pages: 22-30
• [Journal Article] Dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly (2011)
  • Author(s): Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
  • Journal Title: J Neurosci Res Volume: 89 Pages: 815-821
  • Peer Reviewed
• [Journal Article] Extracellular and intraneuronal HMW-AβOs represent a molecular basis of memory loss in Alzheimer's disease model mouse (2011)
  • Author(s): Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E
  • Journal Title: Mol Neurodegener Volume: 6 Pages: 20
  • Peer Reviewed
• [Journal Article] Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy (2011)
  • Author(s): Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, St.George-Hyslop P, Matsubara E, Shoji M
  • Journal Title: J Neurosci Res Volume: 89 Pages: 576-584
  • Peer Reviewed
• [Journal Article] Biomarkers of the dementia (2011)
  • Author(s): Shoji M
  • Journal Title: Int J Alzheimers Dis
• [Journal Article] 神経疾患治療の進歩2010年認知症の治療の進歩 (2011)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 神経治療学 Volume: 28 Pages: 347-350
• [Journal Article] アルツハイマー病の免疫療法 (2011)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: Mebio Volume: 28(5) Pages: 114-126
• [Journal Article] Aβ amyloid accelerates accumulation of phosphorylated tau in neuronal cytoplasm and processes of double transgenic mice (2010)
  • Author(s): Seino Y, Kawarabayashi T, Wakasaya Y, Takamura A, Nakahata N, Watanabe M, Yamamoto-Watanabe Y, Matsubara E, Westaway D, Davis P, St.George-Hyslop P, Shoji M
  • Journal Title: J Neurosci Res Volume: 88 Pages: 3547-3554
  • Peer Reviewed
• [Journal Article] A Japanese ALS6 family with mutation R521C in the FUS/TLS gene a clinical, pathological and genetic report (2010)
  • Author(s): Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
  • Journal Title: J Neurol Sci Volume: 296 Pages: 59-63
  • Peer Reviewed
• [Journal Article] Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3 (2010)
  • Author(s): Yamamoto-Watanabe Y, Watanabe M, Jackson M, Akimoto H, Sugimoto K, Yasujima M, Wakasaya Y, Matsubara E, Kawarabayashi T, Harigaya Y, Lyndon AR, Shoji M
  • Journal Title: Brain Res Volume: 1361 Pages: 140-145
  • Peer Reviewed
• [Journal Article] Prevalence of autosomal dominant cerebellar ataxia in Aomori, the northernmost prefecture of Honshu, Japan (2010)
  • Author(s): Yamamoto-Watanabe Y, Watanabe M, Hikichi M, Ikeda Y, Jackson M, Wakasaya Y, Matsubara E, Kawarabayashi T, Kannari K, Shoji M
  • Journal Title: Internal Med Volume: 49 Pages: 2409-2414
  • Peer Reviewed
• [Journal Article] Plasma antibodies to Aβ40 and Aβ42 (2010)
  • Author(s): Shoji M
  • Journal Title: Hirosaki Medical Journal 61 suppl Pages: S135-141
• [Journal Article] An unusual case of elderly-onset CADASIL with multiple cerebrovascular risk factors (2010)
  • Author(s): Watanabe M, Adachi Y, Jackson M, Yamamoto-Watanabe Y, Wakasaya Y, Shirahama I, Takamura A, Matsubara E, Kawarabayashi T, Shoji M
  • Journal Title: J Stroke Cerebrovasc Dis
  • Peer Reviewed
• [Journal Article] Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy (2010)
  • Author(s): Hirohata M, Yoshita M, Ishida C, Ikeda SI, Tamaoka A, Kuzuhara S, Shoji M, Ando Y, Tokuda T, Yamada M
  • Journal Title: Eur J Neurol Volume: 17 Pages: 823-829
  • Peer Reviewed
• [Journal Article] 神経疾患治療の進歩認知症の治療の進歩 (2010)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 神経治療学 Volume: 27 Pages: 493-498
• [Journal Article] 血管因子からみた認知症 Up To Date:生活習慣病とアルツハイマー型認知症 (2010)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 分子脳血管病 Volume: 9 Pages: 154-159
• [Journal Article] Motor impairment and aberrant production of neurochemicals in human α-synuclein A30P+A53T transgenic mice with α-synuclein pathology (2009)
  • Author(s): Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M
  • Journal Title: Brain Res Volume: 1250 Pages: 232-241
  • Peer Reviewed
• [Journal Article] A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice (2009)
  • Author(s): Ono K, Ikemoto M, Kawarabayashi T, Ikeda M, Nishinakagawa T, Hosokawa M, Shoji M, Takahashi M, Nakashima M
  • Journal Title: J Neurosci Res Volume: 15 Pages: 649-654
  • Peer Reviewed
• [Journal Article] An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis (2009)
  • Author(s): Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M
  • Journal Title: Intern Med Volume: 48 Pages: 1311-1313
  • Peer Reviewed
• [Journal Article] Transthyretin accelerates vascular Aβ deposition in a mouse model of Alzheimer's disease (2009)
  • Author(s): Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S
  • Journal Title: Brain Pathol Volume: 19 Pages: 48-57
  • Peer Reviewed
• [Journal Article] 神経疾患治療の進歩認知症の治療の進歩 (2009)
  • Author(s): 瓦林毅, 東海林幹夫
  • Journal Title: 神経治療学 Volume: 26 Pages: 445-449
• [Presentation] Lipid raftsにおけるAβ oligomerによるtau蓄積の促進 (2011)
  • Author(s): 瓦林毅,若佐谷保仁,仲田祟,高村歩美,中畑直子,松原悦朗,東海林幹夫
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20111113-13
• [Presentation] ものわすれ外来における脳脊髄液バイオマーカー測定の有用性について (2011)
  • Author(s): 瓦林毅,松原悦朗,東海林幹夫
  • Organizer: 第53回老年医学会学術集会
  • Place of Presentation: 新宿
  • Year and Date: 20110615-17
• [Presentation] Aβ oligomerはlipid raftsでtau蓄積を促進する (2011)
  • Author(s): 瓦林毅,若佐谷保仁,松原悦朗,東海林幹夫
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 20110518-20
• [Presentation] アルツハイマー病と軽度認知障害の発症予測スクリーニングマーカーの検証 (2011)
  • Author(s): 松原悦朗,高村歩美,若佐谷保仁,瓦林毅,東海林幹夫
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 20110518-20
• [Presentation] Neuroscience 2010 (2010)
  • Author(s): Kawarabayashi T, Wakasaya Y, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Matsubara E, Shoji M, Factors responsible for neurofibrillary tangle formation and neuronal cell loss in tauopathy brains
  • Organizer: the Society for Neuroscience, 40^<th> Annual Meeting
  • Place of Presentation: San Diego
  • Year and Date: 20101113-17
• [Presentation] DNA microarray解析による神経原線維変化の形成および神経細胞死に関与する因子の解析 (2010)
  • Author(s): 瓦林毅,若佐谷保仁,高村歩美,中畑直子,渡辺有希子,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20101105-07
• [Presentation] Aβ重合体制御よるタウオパチー発症予防の検証 (2010)
  • Author(s): 高村歩美,瓦林毅,東海林幹夫,松原悦朗
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20101105-07
• [Presentation] Factors responsible for neurofibrillary tangle formation and neuronal cell death in tauopathy brains (2010)
  • Author(s): Shoji M, Kawarabayashi T, Wakasaya Y, Takamura A, Watanabe Y, Watanabe M, Matsubara E
  • Organizer: Alzheimer's Association 2010 International Conference on Alzheimer's disease (ICAD)
  • Place of Presentation: Honolulu
  • Year and Date: 20100710-15
• [Presentation] Alzheimer neuronal degeneration : extracellular vs. intracellular Aβ oligomers (2010)
  • Author(s): Takamura A, Kawarabayashi T, Matsubara T, Shoji M, Matsubara E
  • Organizer: Alzheimer's Association 2010 International Conference on Alzheimer's disease (ICAD)
  • Place of Presentation: Honolulu
  • Year and Date: 20100710-15
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版Wechsler memory scale revisedの有用性(第二報) (2010)
  • Author(s): 瓦林毅,中畑直子,松原悦朗,東海林幹夫
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20100624-26
• [Presentation] lipid raftsは神経変性疾患の共通した蛋白凝集開始部位である (2010)
  • Author(s): 瓦林毅,若佐谷保仁,渡辺有希子,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-22
• [Presentation] Aβオリゴマー特異的受動免疫予防法の開発 (2010)
  • Author(s): 松原悦朗,高村歩美,若佐谷保仁,渡辺有希子,中畑直子,渡辺光法,瓦林毅,東海林幹夫
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-22
• [Presentation] ALS6の臨床遺伝および病理学的検討 (2010)
  • Author(s): 渡辺光法,渡辺有希子,岡本幸市,藤田行雄,池田将樹,中里洋一,白濱育美,高村歩美,瓦林毅,松原悦朗,池田佳生,若佐谷保仁,東海林幹夫
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-22
• [Presentation] 複数の脳血管障害のリスクファクターを有し (2010)
  • Author(s): 渡辺光法,足立芳樹,渡辺有希子,白濱育美,高村歩美,中畑直子,若佐谷保仁,瓦林毅,松原悦朗,東海林幹夫
  • Organizer: 第35回脳卒中学会総会
  • Place of Presentation: 岩手
  • Year and Date: 20100415-17
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版Wechsler memory scale revisedの有用性(第二報) (2010)
  • Author(s): 瓦林毅,中畑直子,若佐谷保仁,渡辺有希子,渡辺 光法,高村歩美,松原悦朗,東海林幹夫
  • Organizer: 日本老年医学会 東北地方会
  • Place of Presentation: 福島
  • Year and Date: 2010-10-30
• [Presentation] Factors responsible for neurofibrillary tangle formation and neuronal cell losses in tauopathy brains (2010)
  • Author(s): Kawarabayashi T, Wakasaya Y, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Nakahata N, Matsubara E, Shoji M
  • Organizer: 12th Meeting of Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2010-10-29
• [Presentation] Posterior cortical atrophy の1例 (2010)
  • Author(s): 若佐谷保仁,中畑直子,渡辺有希子,渡辺光法,瓦林毅,松原悦朗,東海林幹夫
  • Organizer: 第87回日本神経学会 東北地方会
  • Place of Presentation: 山形
  • Year and Date: 2010-09-11
• [Presentation] 弘前大学病院もの忘れ外来における脳血管性認知症の検討 (2010)
  • Author(s): 東海林幹夫,瓦林毅,中畑直子,若佐谷保仁,渡辺有希子,渡辺光法,松原悦朗
  • Organizer: 第1回日本脳血管性認知障害研究会
  • Place of Presentation: 東京コンファランスセンター品川
  • Year and Date: 2010-08-28
• [Presentation] Critical illness polyneuropathyを併発した行Musk抗体陽性重症筋無力症の1剖検例 (2010)
  • Author(s): 渡辺有希子,渡辺光法,若佐谷保仁,瓦林毅,松原悦朗,東海林幹夫,若林孝一,佐藤冬樹,鬼島宏,元村政勝
  • Organizer: 第86回日本神経学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2010-03-06
• [Presentation] diagnosis and therapy (2009)
  • Author(s): Shoji M, Recent advances of Alzheimer disease research
  • Organizer: The 2009 International Symposium on Early Detection and Rehabilitation Early Detection and Rehabilitation
  • Place of Presentation: Okayama
  • Year and Date: 20091211-12
• [Presentation] Measurement of cystatin C in cerebrospinal fluid of neurological disorders and analyses of +73 G/A polymorphism (2009)
  • Author(s): Watanabe T, Yamamoto-Watanabe Y, Akimoto H, Sugimoto K, Yasujima M, Kawarabayashi T, Takamura A, Nakahata N, Shirahama I, Wakasaya Y, Matsubara E, Shoji M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] Niemann-Pick type C1遺伝子のloss of functionはlipid raftsでtau蓄積を促進する (2009)
  • Author(s): 瓦林毅,若佐谷保仁,渡辺有希子,中畑直子,高村歩美,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20091120-22
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版Wechsler memory scale revisedの有用性(第二報) (2009)
  • Author(s): 中畑直子,若佐谷保仁,高村歩美,渡辺有希子,渡辺光法,瓦林毅,松原悦朗,東海林幹夫
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20091120-22
• [Presentation] Aβオリゴマー特異的モノクローナル抗体の作用機序とAβオリゴマー毒性発現機序の解明 (2009)
  • Author(s): 高村歩美,岡本康秀,中畑直子,若佐谷保仁,渡辺有希子,渡辺光法,瓦林毅,東海林幹夫,松原悦朗
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20091120-22
• [Presentation] Accumulation of protein in lipid rafts in mouse models of neurodegenerative diseases. Neuroscience 2009 (2009)
  • Author(s): Kawarabayashi T, Wakasaya Y, Seino Y, Takamura A, Nakahata N, Watanabe Y, Watanabe M, Matsubara E, Shoj M
  • Organizer: the Society for Neuroscience,39^<th> Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 20091017-21
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版Wechsler memory scale revised の有用性 (2009)
  • Author(s): 中畑直子,清野祐輔,若佐谷保仁,高村歩美,渡辺有希子,渡辺光法,瓦林毅,松原悦朗,東海林幹夫
  • Organizer: 第11回日本早期認知症学会
  • Place of Presentation: 八戸
  • Year and Date: 20091010-11
• [Presentation] The clinical characterization of the Japanese pedigree of FAD with PS1 H163R mutation (2009)
  • Author(s): Miyagawa T, Iwata A, Kowa H, Kawarabayashi T, Shoji M, Tsuji S, Momose T, Kojima Y
  • Organizer: Alzheimer's Association 2009 International Conference on Alzheimer's disease (ICAD)
  • Place of Presentation: Vienna
  • Year and Date: 20090711-16
• [Presentation] もの忘れ外来の軽度認知障害診断における日本版ウエクスラー記憶検査法(WMS-R)の有効性 (2009)
  • Author(s): 東海林幹夫,中畑直子,瓦林毅,松原悦朗
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20090618-20
• [Presentation] Niemann-Pick type C1遺伝子のloss of functionはlipid raftsでtau蓄積を起こす (2009)
  • Author(s): 瓦林毅,清野祐輔,若佐谷保仁,渡辺有希子,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] Aβアミロイドによるタウ蓄積促進の検討 (2009)
  • Author(s): 清野祐輔,瓦林毅,若佐谷保仁,渡辺有希子,高村歩美,中畑直子,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] Tauopathyによる神経細胞死を誘導する因子の解析 (2009)
  • Author(s): 若佐谷保仁,瓦林毅,清野祐輔,渡辺有希子,渡辺光法,松原悦朗,東海林幹夫
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] 神経変性疾患における脳脊髄液シスタチンC測定の意義 (2009)
  • Author(s): 渡辺光法,渡辺有希子,秋元広之,杉本一博,保嶋実,瓦林毅,高村歩美,中畑直子,白濱育美,若佐谷保仁,清野祐輔,松原悦朗,東海林幹夫
  • Organizer: 50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] ApoE-Aβ複合体がアルツハイマー病患者脳脊髄液中で増加している (2009)
  • Author(s): 松原悦朗,高村歩美,清野祐輔,若佐谷保仁,渡辺有希子,渡辺光法,瓦林毅,東海林幹夫
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] PAとPSPの重要な画像上の鑑別点 (2009)
  • Author(s): 倉田智子,林健,村上哲郎,宮崎一徳,森本展年,太田康之,池田雅美,武久康,永井真貴子,池田佳生,瓦林毅,高尾芳樹,大田泰正,針谷康夫,真邊泰宏,神谷達司,東海林幹夫,阿部康二
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 20090520-22
• [Presentation] 軽度認知障害診断にWechsler memory scale revised は有用である (2009)
  • Author(s): 瓦林毅,中畑直子,渡辺光法,渡辺有希子,若佐谷保仁,松原悦朗,東海林幹夫
  • Organizer: 第20回日本老年医学会東北地方会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-31
• [Presentation] Four-and-a-half LIM domain 1 (FHL1)遺伝子に異常を認めたreducing body myopathyの1例 (2009)
  • Author(s): 瓦林毅,清野祐輔,若佐谷保仁,渡辺有希子,渡辺光法,松原悦朗,東海林幹夫,林由起子,西野一三
  • Organizer: 第85回日本神経学会東北地方会
  • Place of Presentation: 福島
  • Year and Date: 2009-09-12
• [Book] アルツハイマー病の診断マーカー (2011)
  • Author(s): 瓦林毅,東海林幹夫
  • Total Pages: 147-160
  • Publisher: よくわかって役に立つ認知症のすべて 改訂第3版平井俊策編永井書店
• [Book] 日本臨床増刊号認知症学(上)-その解明と治療の最新知見 (2011)
  • Author(s): 瓦林毅
  • Total Pages: 256-261
  • Publisher: 認知症研究に用いられる動物・細胞実験モデル遺伝子改変モデルAPP/PS-1
• [Book] アルツハイマー病モデル.疾患モデルマウス・ラット活用ハンドブック完全版.秋山徹,河府和義,奥山隆平編 (2010)
  • Author(s): 瓦林毅
  • Total Pages: 254-276
  • Publisher: 羊土社,東京
• [Book] 新しい診断と治療のABC66認知症(三村将編集)検査所見2.生化学的マーカ (2010)
  • Author(s): 瓦林毅,東海林幹夫
  • Total Pages: 148-160
  • Publisher: 最新医学社大阪
• [Book] MCIと認知症-リスクファクタ-Annual Review 2009神経 (2009)
  • Author(s): 瓦林毅,東海林幹夫
  • Total Pages: 184-196
  • Publisher: 中外医学社,東京
• [Book] アルツハイマー病
  • Author(s): 東海林幹夫
  • Publisher: 別冊NHKきょうの健康「認知症」(印刷中)
• [Book] 6脳アミロイドーシス(1) アルツハイマー病.別冊・医学のあゆみ(山田正仁編)
  • Author(s): 東海林幹夫
  • Publisher: アミロイドーシス診療のすべて-ガイドライン-完全詳解-(印刷中)
• [Book] アルツハイマー病の診断マーカー
  • Author(s): 東海林幹夫
  • Publisher: よくわかって役に立つ認知症のすべて(改訂第3版).平井俊策編.永井書店(印刷中)
• [Book] 神経内科学テキスト改訂第3版
  • Author(s): 東海林幹夫
  • Publisher: (印刷中)
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/-neurology/index.php
• [Patent(Industrial Property Rights)] アルツハイマー病の検査法 (2010)
  • Inventor(s): 東海林幹夫、渡辺光法
  • Industrial Property Rights Holder: 東海林幹夫、渡辺光法
  • Industrial Property Number: 特願2010-48003
  • Filing Date: 2010-03-24