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2011 Fiscal Year Final Research Report

Induction of regenerative microenvironment around spinal motor neurons by exogenous factors

Research Project

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Project/Area Number 21591070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

AOKI Masashi  東北大学, 大学院・医学系研究科, 教授 (70302148)

Project Period (FY) 2009 – 2011
Keywords筋萎縮性側索硬化症 / 脳神経疾患 / 再生医学
Research Abstract

Amyotrophic lateral sclerosis (ALS)is an adult-onset neurodegenerative disease characterized by selective loss of motor neurons. As compared with vehicle-treated ALS rats, a sequential intrathecal infusion of FGF-2 and EGF followed by hepatocyte growth factor (HGF)resulted in increased neuroblastic cells in the spinal cord of ALS rats, even after the onset of motor neuron disease. It was accompanied by significant suppression of gliogenesis and deposition of chondroitin sulfate. Moreover, angiogenic factors such as FGF-2 and HGF revealed significant neuroprotective effects in ALS rats. Therefore, motor neuron-surrounding microenvironment may be a potential therapeutic target in the future development of regenerative therapy for ALS.

  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Feasibility study for functional test battery of SOD transgenic rat (H46R)and evaluation of edaravone, a free radical scavenger.2011

    • Author(s)
      Aoki M, Warita H, Mizuno H, Suzuki N, Yuki S, Itoyama Y.
    • Journal Title

      Brain Res

      Volume: 1382 Pages: 321-325

    • Peer Reviewed
  • [Journal Article] ALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.2010

    • Author(s)
      Suzuki N, Aoki M, Warita H, Kato M, MizunoH, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
    • Journal Title

      J Hum Genet

      Volume: 55(4) Pages: 252-254

    • Peer Reviewed
  • [Journal Article] Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis.2010

    • Author(s)
      Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, Aoki M.
    • Journal Title

      J Neurol Sci

      Volume: 291(1-2) Pages: 95-101

    • Peer Reviewed
  • [Presentation] Adult skeletal myogenesis in a a rat model of amyotrophic lateral sclerosis.2011

    • Author(s)
      Warita H, Mizuno H, Suzuki N, Itoyama Y, Aoki M.
    • Organizer
      9th Annual Meeting of the Interantional Society for Stem Cell Research.
    • Place of Presentation
      Toronto, Canada.
    • Year and Date
      20110615-18
  • [Presentation] FALS with FUS mutation in Japan with early onset, rapid progress and basophilic inclusion.2010

    • Author(s)
      Aoki M, Suzuki N, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
    • Organizer
      2th International Congress on Neuromuscular Diseases.
    • Place of Presentation
      Naples, Italy.
    • Year and Date
      20100617-22
  • [Presentation] Angiogenesis in the spinal cord of transgenic rats with motor neuron degeneration.2010

    • Author(s)
      Warita H, Aoki M, Mizuno H, Suzuki N, Itoyama Y.
    • Organizer
      12th International Congress on Neuromuscular Diseases.
    • Place of Presentation
      Naples, Italy.
    • Year and Date
      20100617-22
  • [Remarks]

    • URL

      http://www.neurol.med.tohoku.ac.jp/index.html

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Published: 2013-07-31  

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