2011 Fiscal Year Final Research Report
Induction of regenerative microenvironment around spinal motor neurons by exogenous factors
Project/Area Number |
21591070
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Tohoku University |
Principal Investigator |
AOKI Masashi 東北大学, 大学院・医学系研究科, 教授 (70302148)
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Project Period (FY) |
2009 – 2011
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Keywords | 筋萎縮性側索硬化症 / 脳神経疾患 / 再生医学 |
Research Abstract |
Amyotrophic lateral sclerosis (ALS)is an adult-onset neurodegenerative disease characterized by selective loss of motor neurons. As compared with vehicle-treated ALS rats, a sequential intrathecal infusion of FGF-2 and EGF followed by hepatocyte growth factor (HGF)resulted in increased neuroblastic cells in the spinal cord of ALS rats, even after the onset of motor neuron disease. It was accompanied by significant suppression of gliogenesis and deposition of chondroitin sulfate. Moreover, angiogenic factors such as FGF-2 and HGF revealed significant neuroprotective effects in ALS rats. Therefore, motor neuron-surrounding microenvironment may be a potential therapeutic target in the future development of regenerative therapy for ALS.
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[Journal Article] ALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.2010
Author(s)
Suzuki N, Aoki M, Warita H, Kato M, MizunoH, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
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Journal Title
J Hum Genet
Volume: 55(4)
Pages: 252-254
Peer Reviewed
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[Presentation] FALS with FUS mutation in Japan with early onset, rapid progress and basophilic inclusion.2010
Author(s)
Aoki M, Suzuki N, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
Organizer
2th International Congress on Neuromuscular Diseases.
Place of Presentation
Naples, Italy.
Year and Date
20100617-22
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