2011 Fiscal Year Final Research Report
Clarifying the mechanisms of amyloid deposition in familial amyloid polyneuropathy and its application to therapy
| Project/Area Number |
21591076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
KOIKE Huaruki 名古屋大学, 医学部附属病院, 病院助教 (80378174)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Mizuki 名古屋大学, 医学系研究科, 特任助教 (50437042)
IIJIMA Masahiro 名古屋大学, 医学系研究科, COE,特任助教 (40437041)
TANAKA Fumiaki 名古屋大学, 医学系研究科, 准教授 (30378012)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アミロイド / トランスサイレチン / 家族性アミロイドポリニューロパチー / 多発神経炎 |
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| Research Abstract |
We assessed clinicopathological features of FAP ATTR Val30Met patients in Japan by comparing those of conventional early-onset cases from endemic foci to those of late-onset ones from non-endemic areas. Patients with FAP ATTR Val30Met from endemic foci and those from non-endemic areas show different clinical, electrophysiological, and histopathological features. As compared to a classic phenotype of FAP, clinicopathological features of patients from non-endemic areas tend to be nonspecific. Physicians may not take the possibility of FAP into consideration until amyloid became evident by sural nerve biopsy. Therefore, tight recognition for the possibility of FAP ATTR Val30Met are needed at the time of initial evaluation of neuropathy of undetermined etiology to avoid missed diagnosis.
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[Journal Article] Natural history of trans thyretin Val 30 Met familial amyloid polyneuropathy : analysis of late-onset cases from non-endemic areas2012
Author(s)
Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 83
Pages: 152-158
Peer Reviewed
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[Journal Article] Systemic but asymptomatic trans thyretin amyloidosis 8 years after domino liver transplantation2011
Author(s)
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 82
Pages: 1287-1290
Peer Reviewed
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[Journal Article] Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy2011
Author(s)
Hashizume A, Koike H, Kawagashira Y, Banno H, Suzuki K, Ito M, Katsuno M, Watanabe H, Tanaka F, Naganawa S, Kaneko R, Ishii A, Sobue G.
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Journal Title
Clin Neurol Neurosurg
Volume: 113
Pages: 493-495
Peer Reviewed
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[Journal Article] Clinic pathological features of acute autonomic and sensory neuropathy2010
Author(s)
Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, Yasuda T, Fukada Y, Yasui K, Nakashima K, Horiuchi M, Shiomi K, Fukui K, Takashima S, Morita Y, Kuniyoshi K, Hasegawa Y, Toribe Y, Kajiura M, Takeshita S, Mukai E, Sobue G.
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Journal Title
Brain
Volume: 133
Pages: 2881-2896
Peer Reviewed
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[Journal Article] Pyramidal tract involvement in Guillain-Barre syndrome associated withanti-GM1 antibody2010
Author(s)
Tomita M, Watanabe H, Morozumi S, Kawagashira Y, Iijima M, Nakamura T, Katsuno M, Koike H, Hattori N, Hirayama M, Kusunoki S, Sobue G.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 81
Pages: 583-585
Peer Reviewed
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[Journal Article] Distinct characteristics of amyloid deposits in early-and late-onset transthyretinVal30Met familial amyloid polyneuropathy2009
Author(s)
Koike H, Ando Y, Ueda M, Kawagashira Y, Iijima M, Fujitake J, Hayashi M, Yamamoto M, Mukai E, Nakamura T, Katsuno M, Hattori N, Sobue G.
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Journal Title
J Neurol Sci
Volume: 287
Pages: 178-184
Peer Reviewed
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[Journal Article] The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy2009
Author(s)
Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda SI, Sobue G.
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Journal Title
Amyloid
Volume: 15
Pages: 1-7
Peer Reviewed
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[Journal Article] Single nucleotide polymorphism of TAG-1influences IVIg responsiveness of Japanese patients with CIDP2009
Author(s)
Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G.
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Journal Title
Neurology
Volume: 73
Pages: 1348-1352
Peer Reviewed
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[Presentation] Systemic but asymptomatic transthyretin amyloidosis eight years after domino liver transplantation2011
Author(s)
Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G
Organizer
VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
Place of Presentation
Kumamoto, Japan
Year and Date
20111120-22
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[Presentation] Distinct characteristics of amyloid de posits in early-and late-onset transthyretin Val30 Met fami lial amyloid polyneuropathy2009
Author(s)
Koike H, Ando Y, Ueda M, Kawagashira Y, Iijima M, Fujitake J, Hayashi M, Yamamoto M, Mukai E, Hattori N, Sobue G.
Organizer
Peripheral Nerve Society 2009 Biennial Meeting
Place of Presentation
Wurzburg, Germany
Year and Date
20090704-08
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