2011 Fiscal Year Final Research Report
Elucidation of the role of microRNA in the intractable neurological disease
| Project/Area Number |
21591087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University (2011)
Ehime University (2009-2010) |
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Principal Investigator |
KAWANO Yuji 九州大学, 医学研究院, 特任講師 (20333479)
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Tetsurou 愛媛大学, プロテオ医学研究センター, 教授 (00174003)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経難病 / 多発性硬化症 / 筋萎縮性側索硬化症 / microRNA / 疾患感受性遺伝子 |
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| Research Abstract |
In this study, it is aimed for the elucidation of the role of microRNA in the neurologic intractable disease. The 3' UTR of disease-related genes, which is estimated to be regulated by microRNA, were proceeded to determine the entire sequence in the patient to the extent possible. For multiple sclerosis, a total of 14 genes, such as IL2RA and IL7R was selected. With respect to amyotrophic lateral sclerosis, we selected a total of 16 genes such as FUS and Alsin. The significant mutation by a patient by each gene was not found, but we assumed that I was planning to synthesize the result and data with other projects.
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[Journal Article] Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians2011
Author(s)
Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J
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Journal Title
South Japan Multiple Sclerosis Genetics Consortium. Neurology
Volume: 14 ; 76(24)
Pages: 2125-7
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