2011 Fiscal Year Final Research Report
Elucidation of pathogenic mechanisms of myasthenia gravis caused by MuSK antibodies using a new synchronized experimental animal model
| Project/Area Number |
21591102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
SHIGEMOTO Kazuhiro 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40284400)
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| Co-Investigator(Renkei-kenkyūsha) |
KONISHI Tetsuro 独立行政法人国立病院機構宇多野病院, 神経内科, 院長 (50426508)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 重症筋無力症 / 神経筋接合部 / MuSK / 動物疾患モデル / 治療薬 |
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| Research Abstract |
We generated a new animal model in which 100% of mice synchronously develop experimental animal model of myasthenia gravis after immunization with MuSK protein. Our model provides a valuable platform from which to evaluate the role of MuSK signaling in NMJ maintenance and the immune mechanisms and pathophysiology of MuSK-MG, and we propose that 3, 4-DAP may be effective as a symptomatic therapy.
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[Journal Article] 3, 4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis2012
Author(s)
Mori, S., Kishi, M., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Konishi, T., Maruyama, N., and Shigemoto, K
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Journal Title
Journal of neuroimmunology
Volume: 245
Pages: 75-78
DOI
Peer Reviewed
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[Journal Article] Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis2012
Author(s)
Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Nishino, Y., Miyazawa, A., Maruyama, N., and Shigemoto, K
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Journal Title
The American journal of pathology
Volume: 180
Pages: 798-810
DOI
Peer Reviewed
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[Journal Article] Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis2012
Author(s)
Mori, S., Yamada, S., Kubo, S., Chen, J., Matsuda, S., Shudou, M., Maruyama, N., and Shigemoto, K
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Journal Title
Journal of neuroimmunology
Volume: 244
Pages: 1-7
DOI
Peer Reviewed
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[Journal Article] Muscle weakness and neuromuscular junctions in aging and disease2010
Author(s)
Shigemoto, K., Kubo, S., Mori, S., Yamada, S., Akiyoshi, T., and Miyazaki, T
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Journal Title
Geriatr Gerontol Int
Volume: 10
Pages: 137-147
DOI
Peer Reviewed
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