2011 Fiscal Year Final Research Report
An analysis of endothelial activation under cerebral ischemia using liposomes, which targets E-selectin.
| Project/Area Number |
21591106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fujita Health University (2011)
National Center for Geriatrics and Gerontology (2009-2010) |
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Principal Investigator |
WAKITA Hideaki 藤田保健衛生大学, 医学部・内科, 教授 (80416172)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経分子病態学 / 脳血管障害 / 炎症 |
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| Research Abstract |
A novel liposome conjugated to Sialyl Lewis X(SLX-liposome), which targets E-selectin has been developed. In this study, we investigated the capacity of SLX-liposome containing anti-inflammatory agent for neuroprotection in cerebral ischemia using a rat model of transient middle cerebral artery occlusion(TMCAO). SLX-liposomes blocked E-selectin on luminal endothelium and attenuated infarct volume after TMCAO. These results suggest that SLX-liposomes have the potential for the treatment targeted to endothelial cells in acute ischemic stroke.
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[Journal Article] Watershed infarcts in a multiple microembolic model of monkey2011
Author(s)
Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
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Journal Title
Neuroscience Letters
Volume: 499(2)
Pages: 80-83
DOI
Peer Reviewed
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[Journal Article] E-selectin targeting to visualize tumors in vivo2010
Author(s)
Hirai M, Hiramatsu Y, Iwashita S, Otani T, Chen L, Li YG, Okada M, Oie K, Igarashi K, Wakita H, Seno M
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Journal Title
Contrast Media & Molecular Imaging
Volume: 5(2)
Pages: 70-77
DOI
Peer Reviewed
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