2011 Fiscal Year Final Research Report
Establishment of immunoassay system for phosphorylated TDP-43 and the study of the localization of phosphorylated TDP-43 using the immunoelectron microscopy
| Project/Area Number |
21591108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gunma University |
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Principal Investigator |
FUJITA Yukio 群馬大学, 大学院・医学系研究科, 講師 (70420172)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Koichi 群馬大学, 大学院・医学系研究科, 教授 (00124652)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 筋萎縮性側索硬化症 / TDP-43 / FUS / RNA関連蛋白 |
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| Research Abstract |
Several studies about DNA/RNA binding proteins such as TDP-43 and FUS have examined. I found a novel TARDBP gene mutation in familial ALS patients and published the clinical and pathological findings of them in detail. Furthermore, I published the reports about a patient with familial ALS with FUS mutation, a patient with sporadic ALS with numerous FUS-positive inclusions, and the mechanism of neuronal degeneration of the model rats of ALS. I also read the paper about the relationship between TDP-43 and FUS at the international meetings.
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[Journal Article] A Japanese ALS6 family with mutation R521C in the FUS/TLS gene : a clinical, pathological and genetic report2010
Author(s)
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
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Journal Title
J Neurol Sci
Volume: 296
Pages: 59-63
Peer Reviewed
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