Enteric neurodegeneration : an approach to neural system exposed to environments

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Niigata University
• Principal Investigator: OZAWA Tetsutaro 新潟大学, 医歯学総合病院, 講師 (10377153)
• Co-Investigator(Kenkyū-buntansha): NISHIZAWA Masatoyo 新潟大学, 脳研究所, 教授 (80198457) ; TAKAHASHI Hitoshi 新潟大学, 脳研究所, 教授 (90206839)
• Project Period (FY): 2009 – 2011
• Keywords: アルファシヌクレイン / シヌクレイノパチー / 消化管神経 / パーキンソン病 / 多系統萎縮症 / グレリン

Research Abstract

To elucidate the pathogenic mechanism of enteric neurodegeneration in Parkinson's disease(PD) and related disorders, we investigated the frequency of bowel sounds, the state of ghrelin secretion into plasma, and histopathological changes of the enteric nervous system. The results showed that the frequency of bowel sounds and the active ghrelin ratio was significantly lower in patients with PD and multiple system atrophy(MSA) than in control subjects. These observations suggested that enteric nervous system functionally related to gastrointestinal motility and controlling ghrelin secretion was affected in both PD and MSA. Regarding the histopathological changes of the enteric nervous system, Lewy bodies were seen in PD cases ; however, there was no alpha-synuclein positive inclusion in the enteric nervous system in MSA cases. Further investigations are needed to determine neurodegenerative changes of the enteric nervous system in PD and MSA cases.

Research Products

• [Journal Article] 多系統萎縮症における内分泌異常、多系統萎縮症の内分泌異常:自律神経障害との関連 (2012)
  • Author(s): 小澤鉄太郎、高堂裕平、西澤正豊
  • Journal Title: Clinical Neuroscience 2012 Volume: 29 Pages: 228-231
• [Journal Article] Difference in MSA phenotype distribution between populations : genetics or environment? (2012)
  • Author(s): Ozawa T, Revesz T, Paviour D, Lees AJ, Quinn N, Tada M, Kakita A, Onodera O, Wakabayashi K, Takahashi H, Nishizawa M, Holton JL
  • Journal Title: Journal of Parkinson's Disease Volume: 2 Pages: 7-18
  • Peer Reviewed
• [Journal Article] Reduced bowel sounds in Parkinson's disease and multiple system atrophy patients (2011)
  • Author(s): Ozawa T, Saji E, Yajima R, Onodera O, Nishizawa M
  • Journal Title: Clin Auton Res Volume: 21(3) Pages: 181-4
  • Peer Reviewed
• [Journal Article] 多系統萎縮症の自律神経病理:生命維持に関わる領域 (2011)
  • Author(s): 小澤鉄太郎、他田真理、西澤正豊
  • Journal Title: Clinical Neuroscience 2011 Volume: 29 Pages: 974-975
• [Journal Article] Tremulous arytenoid movements predict severity of glottic stenosis in multiple system atrophy (2010)
  • Author(s): Ozawa T, Shinoda H, Tomita M, Shimohata T, Nakayama H, Nishizawa M
  • Journal Title: Mov Disord Volume: 25(10) Pages: 1418-23
  • Peer Reviewed
• [Presentation] パーキンソン病と多系統萎縮症に共通するグレリン分泌異常 (2011)
  • Author(s): 小澤鉄太郎
  • Organizer: 第64回日本自律神経学会総会
  • Place of Presentation: 秋田
  • Year and Date: 20111000
• [Presentation] Plasma ghrelin levels are affected in patients with multiple system atrophy : Evidence of gut-brain axis dysfunction (2011)
  • Author(s): Ozawa T
  • Organizer: 15th International Congress of Parkinson's disease and Movement Disorders
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20110600
• [Presentation] 多系統萎縮症におけるグレリン分泌異常: gut-brainaxis障害の可能性 (2011)
  • Author(s): 小澤鉄太郎
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 20110500
• [Book] 内科(第105巻第6号)、内科疾患の診断基準・病型分類・重症度、IX神経・筋、多系統萎縮症 (2010)
  • Author(s): 小澤鉄太郎、高堂裕平、西澤正豊
  • Publisher: 南江堂