2011 Fiscal Year Final Research Report
Elucidation of the pathogenesis of visual halllucination in Parkinson's disease
| Project/Area Number |
21591111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOU Mizuki 名古屋大学, 医学部附属病院, 助教 (50437042)
SOBUE Gen 名古屋大学, 大学院・医学系研究科, 教授 (20148315)
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| Project Period (FY) |
2009 – 2011
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| Keywords | パーキンソン病 / 幻視 / 認知機能検査 / 視覚認知 / 脳画像 |
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| Research Abstract |
The aim of this study was to elucidate the pathogenesis of visual hallucination(VH) in Parkinson's disease(PD). PD patients showed impairment of the visual perception especially in visual discrimination and figure ground. Voxel-based morphometry showed that PD patients with VH had widespread cortical atrophy including the occipital lobe and nucleus basalis of Meynert compared to normal control. Urinary 8-OHdG values significantly correlated with the score of TUHARS. It is assumed that VH is associated with the combination of functional decline in low-level visual cognition and functional impairment in the high-level visual cognition. In addition, oxidative stress may contribute to VH.
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Research Products
(7 results)
