2011 Fiscal Year Final Research Report
Effects of the anticholinesterase drug to motor end-plates in myasthenia gravis and changes of the protein which constitutes motor end plate
| Project/Area Number |
21591115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHIMURA Toshiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80182822)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOMURA Masakats 長崎大学, 医歯薬学総合研究科, 講師 (70244093)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アセチルコリン / MuSK / 抗体陰性 / 運動終板 / ラット / 微細構造 / 重症筋無力症 |
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| Research Abstract |
We examined fine structural changes in motor end plates which anticholinesterase affected in rats with human anti-MuSK or anti-Acethylcholine receptor(AChR) antibodies. The results can usually use anticholinesterase of the consumption in MG with anti-MuSK autoantibody. We also studied the morphological changes in the MG patients with anti-LRP4, anti-MuSK autoantibody or anti-AChR antibodies as the causative autoantibody of MG, An anti-LRP4 antibody and the anti-MuSK autoantibody induce a same change in motor end plate. The motor end plates in the ColQ defect mouse appeared like a change at the time of the anticholinesterase drug overdosage.
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Research Products
(30 results)
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[Journal Article] Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy : histologic and MRI study2010
Author(s)
Nakamura H, Okada A, Kawakami A, Yamasaki S, Ida H, Masuda T, Fukuda T, Satoh K, Yoshimura T, Nakashima M, Hayashi T, Eguchi K
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Journal Title
Rheumatology international
Volume: 30(10)
Pages: 1381-1383
Peer Reviewed
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[Presentation] Significance of fine structures in motor end-plate in mice with a collagenous sub-unit called Q(ColQ)-deficient mutant mice2010
Author(s)
Yoshimura T, Ito M, Honda Y, Fukudome T, Eric K, Okada N, Takeda S, Motomura M, Tsujino A, Masuda T, Fukuda T, Yoshimura S, Ohno K
Organizer
12th International Congress on Neuromuscular Diseases
Place of Presentation
Naples
Year and Date
20100717-22
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