2011 Fiscal Year Final Research Report
Experimental studies on the therapeutic efficacies of zonisamide on Parkinson disease
| Project/Area Number |
21591118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MIWA Hideto 和歌山県立医科大学, 医学部, 准教授 (50231626)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Ichiro 和歌山県立医科大学, 医学部, 助教 (40364088)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Tomoyoshi 和歌山県立医科大学, 医学部, 教授 (50103891)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ゾニザミド / 振戦 / パーキンソン病 / T型カルシウムチャンネル |
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| Research Abstract |
Zonisamide is an anti-epileptic drug, and it can be used for treatment of Parkinson disease(PD). However, the pharmacological mechanisms underlying the anti-parkinsonian effects remain unclear. In the present study, we performed animal experiments using experimental tremor models, and could obtain data suggesting that not only zonisamide but also the other T-type calcium channel blockers have the anti-tremor effect. It is expected that T-type calcium channel would be a new therapeutic target of tremors.
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