2011 Fiscal Year Final Research Report
Regulation of insulin resistance by adipose tissue M1/M2 macrophages.
| Project/Area Number |
21591126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
TOBE Kazuyuki 富山大学, 大学院・医学薬学研究部(医学), 教授 (30251242)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISAKA Shiho 富山大学, 大学病院, 医員 (30512082)
KOSHIMIZU Yukiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (30511828)
SHINODA Kouichirou 富山大学, 大学院・医学薬学研究部(医学), 助教 (40377312)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肥満 / 脂肪組織 / 炎症 / インスリン抵抗性 / マクロファージ |
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| Research Abstract |
In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications(Diabetes 58 : 2574-2582, 2009). I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.
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[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
Author(s)
Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T., Ogawa Y., Tobe K., Takatsu K., and Nagai Y
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Journal Title
Peer Reviewed
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[Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011
Author(s)
Fujisaka S, Usui I, Kanatani Y, Ikutani M, Takasaki I, Tsuneyama K, Tabuchi Y, Bukhari A, Yamazaki Y, Suzuki H, Senda S, Aminuddin A, Nagai Y, Takatsu K, Kobayashi M, Tobe K
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Journal Title
Endocrinology
Volume: 152(5)
Pages: 1789-99
Peer Reviewed
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[Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286 Asp) transgenic mice2011
Author(s)
Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., Tobe K., Sasahara M
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Journal Title
Diabetologia
Volume: 54
Pages: 2953-2962
Peer Reviewed
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[Journal Article] Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice2009
Author(s)
Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, Tsuneyama K, Nagai Y, Takatsu K, Urakaze M, Kobayashi M, Tobe K
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Journal Title
Diabetes
Volume: 58
Pages: 2574-2582
Peer Reviewed
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[Journal Article] Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice2009
Author(s)
Yamazaki Y, Usui I, Kanatani Y, Matsuya Y, Tsuneyama K, Fujisaka S, Bukhari A, Suzuki H, Senda S, Imanishi S, Hirata K, Ishiki M, Hayashi R, Urakaze M, Nemoto H, Kobayashi M, Tobe K
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 297
Pages: E1179-E1186
Peer Reviewed
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[Journal Article] Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{ alpha} from 3T3-L1 preadipocytes2009
Author(s)
Asamizu S, Urakaze M, Kobashi C, Ishiki M, Norel Din AK, Fujisaka S, Kanatani Y, Bukahari A, Senda S, Suzuki H, Yamazaki Y, Iwata M, Usui I, Yamazaki K, Ogawa H, Kobayashi M, Tobe K
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Journal Title
J Endocrinol
Volume: 202
Pages: 199-205
Peer Reviewed
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[Journal Article] Characterization of diabetic nephropathy in CaM kinase IIalpha(Thr286Asp) transgenic mice2009
Author(s)
Suzuki H, Kato I, Usui I, Takasaki I, Tabuchi Y, Oya T, Tsuneyama K, Kawaguchi H, Hiraga K, Takasawa S, Okamoto H, Tobe K, Sasahara M
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Journal Title
Biochem Biophys Res Commun
Volume: 379
Pages: 38-42
Peer Reviewed
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