2011 Fiscal Year Final Research Report
Characterization of autoantibody against Amylaseα-2A in patients with fulminant type 1 diabetes mellitus and autoimmune pancreatitis, and its clinical use.
| Project/Area Number |
21591127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
ENDO Toyoshi 山梨大学, 大学院・医学工学総合研究部, 准教授 (00152017)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuro 山梨大学, 大学院・医学工学総合研究部, 教授 (30113442)
KANESHIGE Masahiro 山梨大学, 医学部附属病院, 助教 (20377518)
TAKIZAWA Souichi 山梨大学, 大学院・医学工学総合研究部, 助教 (80456467)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エネルギー / 糖質代謝異常 |
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| Research Abstract |
Fulminant type 1 diabetes mellitus(FT1DM) is a subtype of T1DM, which frequently induces diabetic ketoacidosis. However, no useful marker for rapid diagnosis of FT1DM exsist. We reported that patients with FT1DM have an autoantibody against Amylaseα-2A(AMY), and developed a enzyme linked immunosorbent assay(ELISA) for detecting the antibody. Because background in the system is relatively high, so, we have improved ELISA using synthetic peptide corresponding AMY as a new antigen. When we employed peptide-7 as an antigen, we obtained good results for detecting AMY autoantibody from patients with FT1DM(sensitivity 94. 3%, specificity 93. 7% by ROC analysis), which might applicable for clinical use for rapid diagnosis of FT1DM.
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[Journal Article] Type 1 Diabetes and Interferon Therapy : Anationwide survey in Japan.; the Research Committee on Type 1 Diabetes of the Japan Diabetes Society2011
Author(s)
Nakamura K, Kawasaki E, Imagawa A, Awata T, Ikegami H, Uchigata Y, Kobayashi T, Shimada A, Nakanishi K, Makino H, Maruyama T, Hanafusa T
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Journal Title
Diabetes Care
Volume: 34
Pages: 2084-2089
Peer Reviewed
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[Journal Article] RIG-I-and MDA5-Initiated Innate Immunity Linked With Adaptove Immunity Acceleratesβ-Cell Death in Fulminant Type 1Diabetes2011
Author(s)
Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, and Tetsuro Kobayashi
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Journal Title
Diabetes
Volume: 60
Pages: 884-889
Peer Reviewed
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[Journal Article] on behalf of the Japanese Study Group on Type 1 Diabetes Genetics ; Association of Type 1 Diabeteswith Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunityin Japanese2009
Author(s)
Takuya Awata, Eiji Kawasaki, Shoichiro Tanaka, Hiroshi Ikegami, Taro Maruyama, Akira Shimada, Koji Nakanishi, TetsuroKobayashi, Hiroyuki Iizuka, Miho Uga, Yumiko Kawabata, Yasuhiko Kanazawa, Susumu Kurihara, Masataka Osaki, Shigehiro Katayama
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Journal Title
J Clin. Endocrinol. Metab
Volume: 94
Pages: 231-235
Peer Reviewed
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[Journal Article] Japanese Study Group on Type 1 Diabetes Genetics ; Genetic Association between the Interleukin-2 Receptor-αGene and Modeof Onset of Type 1 Diabetes in the Japanese Population2009
Author(s)
Eiji Kawasaki, Takuya Awata, HiroshiIkegami, Tetsuro Kobayashi, TaroMaruyama, Koji Nakanishi, Akira Shimada Miho Uga, Susumu Kurihara, Yumiko Kawabata, Shoichiro Tanaka, Yasuhiko Kanazawa, Katsumi Eguchi
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Journal Title
J Clin Endocrionl Metab
Volume: 94
Pages: 947-952
Peer Reviewed
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