2011 Fiscal Year Final Research Report
Elucidation of molecular basis of pancreatic beta-cell regeneration from pancreatic acinar cells
| Project/Area Number |
21591137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
MINAMI Kohtaro 神戸大学, 大学院・医学研究科, 准教授 (80334176)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エネルギー / 糖代謝異常 / 再生医療 |
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| Research Abstract |
Generation of surrogate beta-cells(insulin-secreting cells) is a promising approach toward development of regenerative medicine in diabetes mellitus. In this study, it has been shown that insulin-secreting cells can be generated from human pancreatic exocrine cells. It also has been found that pancreatic beta-cells change their phenotype(dedifferentiation, proliferation, and redifferentiation) under certain conditions. In addition, it has been revealed that new pancreatic beta-cells are generated by neogenesis form non-beta-cells in vivo after birth.
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Research Products
(34 results)
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[Journal Article] PGRN is a key adipokine mediating high-fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue2012
Author(s)
Matsubara T, Kagawa A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E, Nishimura O, and Seino S
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Journal Title
Cell Metab
Volume: 15(1)
Pages: 38-50
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