2011 Fiscal Year Final Research Report
Development of treatment for the inhibition of type 1 diabetes
| Project/Area Number |
21591143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nagasaki University |
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Principal Investigator |
ABIRU Norio 長崎大学, 大学院・医歯薬学総合研究科, 講師 (00380981)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Masakazu 長崎大学, 医歯薬学総合研究科, 客員研究員 (00380874)
SATOH Tsuyoshi 長崎大学, 大学病院, 医員 (70437896)
KURIYA Genpei 長崎大学, 大学病院, 医員 (50457579)
NAKAMURA Kan 長崎大学, 大学病院, 医員 (70530426)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAYAMA Yuji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30274632)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 1型糖尿病 / NODマウス / インスリン / 経鼻免疫 / polyI : C |
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| Research Abstract |
In order to develop the treatment for the inhibition of type 1 diabetes, we evaluated the combination treatments with intra-nasal(i. n.) and subcutaneous(sub-Q) autoantigen administration for diabetes inhibition in the NOD mice. The mice treated with combination of i. n. insulin B-chain peptide/ polyI : C and a single sub-Q insulin peptide/ Alum exhibited less development of diabetes compared to those with single subQ-peptide/ Alum alone or control mice. However, such combination treatments did not alter population of regulatory T cells.
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[Journal Article] Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes2011
Author(s)
E Kawasaki, K Nakamura, G Kuriya, T Satoh, M Kobayashi, H Kuwahara, N Abiru, H Yamasaki, N Matsuura, J Miura, Y Uchigata, K Eguchi
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Journal Title
Diabetes Metab Res Rev
Volume: 27(8)
Pages: 895-898
Peer Reviewed
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[Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse2011
Author(s)
T Satoh, N Abiru, N Kobayashi, H Zhou, K Nakamura, G Kuriya, H Nakamura, Y Nagayama, E Kawasaki, H Yamasaki, L Yu, GS Eisenbarth, E Araki, M Mori, S Oyadomari, K Eguchi
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Journal Title
Apoptosis
Volume: 6(4)
Pages: 438-48
Peer Reviewed
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[Journal Article] Differences in the humoral autoreactivity to zinc transporter 8 between childhood-and adult-onset type 1 diabetes in Japanese patients2011
Author(s)
E Kawasaki, K Nakamura, G Kuriya, T Satoh, M Kobayashi, H Kuwahara, N Abiru, H Yamasaki, N Matsuura, J Miura, Y Uchigata, K Eguchi
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Journal Title
Clin Immunol
Volume: 138(2)
Pages: 146-153
Peer Reviewed
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