2011 Fiscal Year Final Research Report
Identification of novel molecules associated with insulin action or insulin secretion induced by mild electric current and hyperthermia therapy
| Project/Area Number |
21591145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
KONDO Tatsuya 熊本大学, 大学院・生命科学研究部, 助教 (70398204)
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| Co-Investigator(Kenkyū-buntansha) |
EIICHI Araki 熊本大学, 大学院・生命科学研究部, 教授 (10253733)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖尿病 / HSP72 / インスリン抵抗性 |
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| Research Abstract |
Activation of heat shock response with Mild Electrical stimulation with hyperThermia(MET) improves metabolic profiles and insulin resistance in type2diabetic mice and humans. In this study, we identified several target genes such as AMPK, Sirt1 or PG-1α, which are involved in the effect of MET in insulin sensitive tissues.
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[Journal Article] Hyperthermia with Mild Electrical Stimultation Protects Pancreatic b-Cells From Cell Stresses and Apoptosis2012
Author(s)
Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
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Journal Title
Diabetes
Volume: 61(4)
Pages: 838-47
Peer Reviewed
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[Journal Article] Glucose uptake in rat skeletal muscle L6cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase(PI-3K)/Akt pathway2011
Author(s)
Yano S, Morino-Koga S, Kondo T, Suico MA, Koga T, Shimauchi Y, Matsuyama S, Shuto T, Sato T, Araki E, Kai H
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Journal Title
J Pharmacol Sci
Volume: 115(1)
Pages: 94-8
Peer Reviewed
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[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
Author(s)
Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 29(5)
Pages: E764-71
Peer Reviewed
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[Journal Article] The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling2010
Author(s)
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Aleman JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR
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Journal Title
Cancer Res
Volume: 70(13)
Pages: 5305-15
Peer Reviewed
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[Journal Article] Unique Roles of the p110a Isoform of Phosphoinositide3-kinase in Hepatic Insulin Signaling and Metabolic Regulation2010
Author(s)
Rotter, VS., Liu, P., Suzuki, R., Kondo, T., Winnay, J., Tran, TT., Asano, T., Smyth, G., Sajan, MP., Farese, RV., Kahn, CR and Zhao, JJ
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Journal Title
Cell Metab
Volume: 11(3)
Pages: 220-30
Peer Reviewed
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[Journal Article] Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine2010
Author(s)
Kondo, T., Goto, R., Sonoda, K., Yasuda, T., Ono, K., Takaki, Y., Yatsuda, R., Miyamura, N., and Araki, E
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Journal Title
Internal Med
Volume: 49(7)
Pages: 637-43
Peer Reviewed
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[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010
Author(s)
Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Ts uruzoe, K., Furukawa, N., Motoshima, H., Mori no, S., Yamashita, Y., Miyamura, N., Kai, H. and Araki, E
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Journal Title
Obesity Res. Clin. Pract
Volume: 4(2)
Pages: e101-e109
Peer Reviewed
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[Journal Article] A case of ectopic adrenocorticotropic hormoneproducing pancreatic neuroendocrine tumor with multiple liver metastases2010
Author(s)
Kondo, T., Matsuyama, R., Ashihara, H., Matsuo, Y., Sasaki, K., Goto, R., Ono, K., T akaki, Y., Honda, Y., Iyama, K., Kawashima, J., Motoshima, H., Tsuruzoe, K., Miyamura, N. and Araki, E
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Journal Title
Endocrine J
Volume: 57(3)
Pages: 229-236
Peer Reviewed
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[Journal Article] A case of primary thyroid squamous cell cancer : transformation from benign tumour associated with chronic thyroiditis?2009
Author(s)
Kondo, T., Matsuyoshi, A., Matsuyoshi, H., Goto, R., Ono, K., Honda, Y., Iyama, K., Tsu ruzoe, K., Miyamura, N. and Araki, E
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Journal Title
DOI
Peer Reviewed
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[Journal Article] A novel combination of mild electrical stimulation and hyperthermia : general concepts and applications2009
Author(s)
Kai, H., Suico, MA., Morino, S., Kondo, T., Oba, M., Noguchi, M., Shuto, T., and Araki, E
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Journal Title
Int J Hyperthermia
Volume: 25(8)
Pages: 655-60
Peer Reviewed
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[Presentation] Activation of Heat Shock Response Improves Metabolic Profiles in Male Subjects with Metabolic Syndrome and Type2Diabetes2011
Author(s)
Kondo T, Matsuyama R, Miyagawa K, Goto R, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
Organizer
16th Japan-Korea Symposium on Diabetes Mellitus
Place of Presentation
Tokyo, Hilton Tokyo Bay Hotel, Japan
Year and Date
20111021-22
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[Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type2Diabetes2010
Author(s)
Kondo T, Matsuyama R, Sasaki K, Morino-Koga S, Suico MA, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
Organizer
46th EASD Annual Meeting 20～ 24 Sept
Place of Presentation
Stockholm, Sweden
Year and Date
20100920-24
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[Presentation] Knockdown of CHOP, an Inducer of Cellular Apoptosis upon Exesssive Endoplasmic Reticulum Stress, in Liver Ameliorates Insulin Resistance and Glucose Homeostasis in Mice Model of Type2Diabetes2009
Author(s)
Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M, Araki E
Organizer
45th EASD Annual Meeting
Place of Presentation
Vienna, Austria
Year and Date
20090929-1002
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[Presentation] Araki E2009
Author(s)
Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M
Organizer
69th American Diabetes Association Scientific Sessions
Place of Presentation
New Orleans, USA
Year and Date
20090605-09
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