2011 Fiscal Year Final Research Report
Development of the treatment for fulminant type1 diabetes using the model mouse
| Project/Area Number |
21591149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SANO Hiroyuki 大阪医科大学, 医学部, 助教 (20556435)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 劇症1型糖尿病 / encephalomyocarditis virus / GLP-1 / マクロファージ |
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| Research Abstract |
This study has shown that exendin-4 suppresses the onset of encephalomyocarditis virus(EMCV) induced diabetes, which is a model of fulminant type 1 diabetes. Exendin-4 markedly reducedβ cell destruction by inhibiting the infiltration of macrophages into the islets and the expression of EMCV infected macrophage derived chemical mediators, TNF-α, IL-1β and iNOS. Our study clarified that it could be an important strategy to suppress macrophage activation in the treatment of fulminant type1 diabetes.
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