Study on the mechanism of longevity effect by adiponectin

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kurume University
• Principal Investigator: YAMADA Kentaro 久留米大学, 医学部, 教授 (10191305)
• Co-Investigator(Kenkyū-buntansha): OTABE Shuichi 久留米大学, 医学部, 助教 (70194553) ; NAKAYAMA Hitomi 久留米大学, 医学部, 助教 (20368955)
• Project Period (FY): 2009 – 2011
• Keywords: メタボリックシンドローム / アディポネクチン / 寿命 / 老化 / KK/Taマウス / 慢性炎症 / Klothoマウス

Research Abstract

Hyperadiponectinemia induced by transgenic expression of adiponectin prevented the premature death of metabolic syndrome model mice without affecting body weight or food ingestion. The longevity effect was not attributable to the suppression of malignant tumors or vascular events, or the augmentation of Sirt1. Anti-inflammatory action through the inhibition of AKT signaling may be involved in the beneficial effect of adiponectin. On the other hand, adiponectin did not prevent the premature death of Klotho mice.

Research Products

• [Journal Article] Hyperadipo-nectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation (2012)
  • Author(s): Otabe S, Wada N, Hashinaga T, Yuan X, Shimokawa I, FukutaniT, Tanaka K, Ohki T, Kakino S, Kurita Y, Nakayama H, Tajiri Y, Yamada K
  • Journal Title: Journal of Endocrinology Volume: 213 Pages: 67-76
  • DOI: DOI:10.1530/JOE-11-0329
  • Peer Reviewed
• [Presentation] Effects of adiponectin on the life span of Klotho mice : From the generation of Klotho mice over-expressing adiponectin gene (2011)
  • Author(s): Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Yamada K
  • Organizer: 71st Scientific Sessions of American Diabetes Association
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 20110624-28
• [Presentation] 日本人の体質と健康寿命を延ばす食習慣 (2011)
  • Author(s): 山田研太郎
  • Organizer: 第2回健康生きがい学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-23
• [Presentation] Adiponectin Possesses Preventive Effect on Premature Death from the Metabolic Syndrome (2010)
  • Author(s): Otabe S, Hashinaga T, Yuan X, Fukutani T, Ohki T, Kakino S, Wada N, Kurita Y, Nakayama H, Tajiri Y, Shimokawa Y, Yamada K
  • Organizer: 70th Scientific Sessions, American Diabetes Association
  • Place of Presentation: 米国オーランド
  • Year and Date: 20100625-29
• [Presentation] アディポネクチンはメタボリックシンドロームによる短命化を防ぎうる-高アディポネクチン血症・KK/Taマウスの作製から- (2010)
  • Author(s): 小田邊修一, 橋永俊彦, 原暁紅, 福谷知香, 大木剛, 柿野聡美, 和田暢彦, 栗田弥生, 中山ひとみ, 田尻祐司, 下川功, 山田研太郎
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29