2011 Fiscal Year Final Research Report
Elucidation of the role of CITED2 in hepatic glucose production
| Project/Area Number |
21591155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
MATSUMOTO Michihiro 独立行政法人国立国際医療研究センター, 研究所・糖尿病研究センター・分子代謝制御研究部, 部長 (90467663)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Kenjiro (80533736)
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| Research Collaborator |
SAKAI Mashito
TSUJIMURA Tomoko
CAO Yongheng
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| Project Period (FY) |
2009 – 2011
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| Keywords | CITED2 / 遺伝子転写 / 糖尿病 / インスリン / グルカゴン |
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| Research Abstract |
We unveiled that CITED2 functions as a transducer of glucagon and insulin signaling in the regulation of PGC-1αactivity that is associated with the transcriptional control of gluconeogenesis and that this function is mediated through the modulation of GCN5-dependent PGC-1αacetylation. We also found that loss of hepatic CITED2 function suppresses gluconeogenesis in diabetic mice, suggesting it as a therapeutic target for hyperglycemia.
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Research Products
(15 results)
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[Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC12011
Author(s)
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Matsumoto M, Kasuga M, Kido Y
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Journal Title
PLoS One
Volume: 6
Pages: e23238
URL
Peer Reviewed
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