2011 Fiscal Year Final Research Report
Involvement of ABCA1 transporter in the regulation of anti-atherogenic sphingosine-1-phosphate content in plasma and high-density lipoprotein
| Project/Area Number |
21591158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Koichi 群馬大学, 生体調節研究所, 准教授 (00302498)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ABCA1トランスポ.タ. / スフィンゴシン1-リン酸 / リポ蛋白質 / スフィンゴシン / HDL / 抗動脈硬化性脂質 / ApoA-I / スフィンゴシンキナーゼ |
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| Research Abstract |
Sphingosine 1-phosphate (S1P) is accumulated in plasma high-density lipoprotein (HDL), which induces anti-atherogenic actions in endothelial and smooth muscle cells. However, it remains uncharacterized how extracellular S1P is produced and accumulated in HDL particles. This study has focused on the relationship between S1P accumulation in HDL particles and lipoprotein formation by ATP-binding cassette transporter A1 (ABCA1 transporter). Our results using ABCA1 transporter-deficient and lecithin-cholesterol acyltransferase-deficient mice suggested that ABCA1 transporter may be involved in the accumulation of S1P in HDL particles.
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[Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo2012
Author(s)
Mayumi Komachi, Koichi Sato, Masayuki Tobo, Chihiro Mogi, Takayuki Yamada, Hideo Ohta, Hideaki Tomura, Takao Kimura, Dong-Soon Im, Keisuke Yanagida, Satoshi Ishii, Izumi Takeyoshi, Fumikazu Okajima
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Journal Title
Cancer Sci
Volume: (in press)
Peer Reviewed
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[Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages, Biochem2011
Author(s)
Shinichi Matsuzaki, Tamotsu Ishizuka, Hidenori Yamada, Yosuke Kamide, Takeshi Hisada, Isao Ichimonji, Haruka Aoki, Masakiyo Yatomi, Mayumi Komachi, Hiroaki Tsurumaki, Akihiro Ono, Yasuhiko Koga, Kunio Dobashi, Chihiro Mogi, Koichi Sato, Hideaki Tomura, Masatomo Mori, Fumikazu Okajim, Fumikazu Okajim
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Journal Title
Biophys. Res. Commun
Volume: Vol.413
Pages: 499-503
Peer Reviewed
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[Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010
Author(s)
Jin-Peng Liu, Mayumi Komachi, Hideaki Tomura, Chihiro Mogi, Alatangaole Damirin, Masayuki Tobo, Mutsumi Takano, Hiromi Nochi, Koichi Tamoto, Koichi Sato, Fumikazu Okajima
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Journal Title
Am. J. Physiol. Heart Circ. Physiol
Volume: Vol.299
Pages: H731-H742
Peer Reviewed
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[Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010
Author(s)
Jin-Peng Liu, Takashi Nakakura, Hideaki Tomura, Masayuki Tobo, Chihiro Mogi, Ju-Qiang Wang, Xiao-Dong He, Mutsumi Takano, Alatangaole Damirin, Mayumi Komachi, Koichi Sato, Fumikazu Okajima
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Journal Title
Pharmacol. Res
Volume: Vol.61
Pages: 499-505
Peer Reviewed
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[Presentation] Each one of specified histidine residues in GPR4 is important for acidic pH-induced stimulation of multiple signaling pathways2010
Author(s)
Hideaki Tomura, Jin-Peng Liu, Takashi Nakakura, Masayuki Tobo, Chihiro Mogi, Xiao-Dong He, Mutsumi Takano, Mayumi Komichi, Masashi Ebara, Ayaka Matsui, Koichi Sato, Fumikazu Okajima
Organizer
BMB2010(日本分子生物学会年会、日本生化学会)
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
20101207-10
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