2011 Fiscal Year Final Research Report
Newly identification of transcriptional regulators related to fructose-induced hepatic lipogenesis
| Project/Area Number |
21591162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質代謝異常 |
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| Research Abstract |
Fructose intake induced O-GlcNAc modification of RNA-binding motief protein on X chromosome(RBMX), which related to the activation of SREBP-1c in the mouse liver. The abnormal regulation of hexosamine-signaling pathway and O-GlcNAc cycling reflected on the genetic susceptibility to hepatic lipogenesis and metabolic disorders induced by high fructose diet
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[Journal Article] SAFB1, an RBMX-Binding Protein, is a Newly Identified Regulator of Hepatic SREBP-1c Gene2009
Author(s)
Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Maeno Y, Obata T, Ugi S, Maegawa H, Kimura H, Kashiwagi A.
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Journal Title
BMB reports
Volume: 42
Pages: 232-237
Peer Reviewed
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