2011 Fiscal Year Final Research Report
Does nicotinic acid increase HDL-cholesterol through activation of longevity factor SIRT1?
| Project/Area Number |
21591163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質代謝異常 / コレステロール |
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| Research Abstract |
To see whether nicotinic acid exerts its anti-hyperlipidemic effect through SIRT1 activation, expression of possible target genes of SIRT1, ABCA1 and CYP7A, in nicotinic acid administrated rat liver was examined. No change of the genes with marked increase in NAD has been observed so far.
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