2011 Fiscal Year Final Research Report
Roles of ABC transporters in cellular cholesterol transport and inflammatory response
| Project/Area Number |
21591164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nagoya City University |
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Principal Investigator |
ABE-DOHMAE Sumiko 名古屋市立大学, 大学院・医学研究科, 准教授 (70227700)
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| Co-Investigator(Kenkyū-buntansha) |
KURONO Chieko 名古屋市立大学, 大学院・医学研究科, 助教 (50080049)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOYAMA Shinji 中部大学, 応用生物学部, 教授 (10142192)
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| Project Period (FY) |
2009 – 2011
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| Keywords | HDL / ABCA1 / ABCA7 / phagocytosis |
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| Research Abstract |
We found that insulin impairs through modulation of ABCA1 activity by two different mechanisms. One is enhancement of ABCA1 protein degradation and the other is lowering the ABCA1 specific activity. We also confirmed that ABCA7enhances phagocytosis, which can be further augmented by apolipoproteins and statins.
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[Journal Article] Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis2009
Author(s)
Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S
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Journal Title
J Lipid Res
Volume: 50(11)
Pages: 2299-2305
DOI
Peer Reviewed
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