2011 Fiscal Year Final Research Report
The study of the interactions between muscle and bone/mineral metabolism.
| Project/Area Number |
21591179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kinki University (2011)
Kobe University (2009-2010) |
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Principal Investigator |
KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 筋 / 骨 / 骨芽細胞 / 分化 / シグナル |
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| Research Abstract |
The aim of our study is the identification of local ossification factors in muscle tissues and humoral bone anabolic factors produced from muscles in order to clarify the interactions between muscle and bone/mineral metabolism. We selected the factors with bone formation activity using the comprehensive gene analysis between muscle-derived cells and ossification signal-enhanced cells. Among them, Tmem119 is expected the factor, which locally induces muscle ossification. On the other hand, osteoglycin and FAM5C may be the candidates of novel humoral bone anabolic factors produced from muscles. We would like to proceed the further study of these factors as the putative targets for the development of the treatment of osteoporosis.
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[Journal Article] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway2011
Author(s)
Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H
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Journal Title
J Biol Chem
Volume: 286
Pages: 9787-9796
DOI
Peer Reviewed
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