2011 Fiscal Year Final Research Report
Identification of key molecules by the analysis of pancreatic autopsy specimens in the development of fulminant type 1 diabetes
| Project/Area Number |
21591184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 劇症1型糖尿病 / 自然免疫 / toll-like receptor / ケモカイン |
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| Research Abstract |
We analyzed pancreas specimens soon after the onset of fulminant type 1 diabetes. We revealed the expression of viral receptor and enterovirus RNA. The expressions of chemokine and its receptor were also observed. They are candidates of key molecules and viral infection, activation of innate immunity and homing of immunocytes by chemokine interaction may contribute to the development of fulminant type 1 diabetes.
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