2011 Fiscal Year Final Research Report
Identification and functional analysis of novel bioactive peptides associated with feeding regulation and lifestyle-related disease
Project/Area Number |
21591189
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
MIYAZATO Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
|
Co-Investigator(Renkei-kenkyūsha) |
KANGAWA Kenji 独立行政法人国立循環器病研究センター, 研究所, 所長 (00112417)
DATE Yukari 宮崎大学, フロンティア科学実験総合センター, 教授 (70381100)
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Project Period (FY) |
2009 – 2011
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Keywords | ペプチド / 摂食調節 / 生活習慣病 / オーファン受容体 |
Research Abstract |
To search for novel bioactive peptides associated with feeding regulation and lifestyle-related diseases, we used the orphan receptor strategy and newly established methods to find some candidates as novel bioactive substances. By using gene deficient mice of ghrelin or neuromed in S(NMS), we demonstrated that endogenous ghrelin suppresses sympathetic nerve activity and improves the prognosis after acute myocardial infarction, and that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system.
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[Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-protein-coupled receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagae K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 414
Pages: 44-48
DOI
Peer Reviewed
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[Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011
Author(s)
Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Pages: 872-877
DOI
Peer Reviewed
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[Journal Article] Impaired recovery of blood flow following hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides2009
Author(s)
Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 29
Pages: 1516-1521
DOI
Peer Reviewed
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