The effect of ghrelin on hepatocyte proliferation and regenerative liver growth via the autonomic nervou s system

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591190
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: HOSODA Hiroshi 独立行政法人国立循環器病研究センター, 再生医療部, 室長 (40359807)
• Co-Investigator(Kenkyū-buntansha): MIYAZATO Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
• Co-Investigator(Renkei-kenkyūsha): KANGAWA Kenji 独立行政法人国立循環器病研究センター, 研究所, 部長 (00112417)
• Project Period (FY): 2009 – 2011
• Keywords: グレリン / 生理活性ペプチド / 神経科学 / 再生医学

Research Abstract

The liver is richly innervated, and the autonomic nervous system regulates hepatic functions, such as hepatic regeneration and apoptosis, and metabolic control. Because ghrelin participates in the central regulation of gastric functions through vagal nerve pathway, we have explored the effect of ghrelin on the neural regulation of hepatic functions. In a rat model of lethal liver cirrhosis produced by dimethylnitrosamine, repeated ghrelin administration reduces the collagen deposition and hepato cyte apoptosis, and accelerates hepatocyte proliferation and normalization of liver function, resulting in the recovery from lethal hepatic failure. Ghrelin also promotes regenerative liver growth in seventy-percent partial hepatectomized rats. Thus, ghrel in may serve as a new neuroendocrinologic approach for improving hepatic functions and accelerating liver regeneration in-patients with liver cirrhosis and hepatic resection.

Research Products

• [Journal Article] Transgenic overexpression of intraislet ghrelin does not affect insulin secret ion or glucose metabolism in vivo (2012)
  • Author(s): Bando M, Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 302 Pages: 403-408
  • DOI: DOI:10.1152/ajpendo.00341.2011
  • Peer Reviewed
• [Journal Article] Generation of transgenic mice overexpressing a ghrelin analog (2010)
  • Author(s): Yamada G, Ariyasu H, Iwakura H, Hosoda H, Akamizu T, Nakao K, Kangawa K
  • Journal Title: Endocrinology Volume: 151 Pages: 5935-5940
  • DOI: DOI:10.1210/en.2010-0635
  • Peer Reviewed
• [Journal Article] Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents (2009)
  • Author(s): Hiejima H, Nishi Y, Hosoda H, Yoh J, Mifune H, Satou M, Sugimoto H, Chiba S, Kawahara Y, Tanaka E, Yoshimatsu H, Uchimura N, Kangawa K, Kojima M
  • Journal Title: Regul Pept Volume: 156 Pages: 47-56
  • DOI: DOI:10.1016/j.regpep.2009.05.003
  • Peer Reviewed
• [Presentation] グレリンはラット肝切除後の肝再生を促進する (2009)
  • Author(s): 細田洋司
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館
  • Year and Date: 2009-04-23
• [Book] 日本臨床、肥満症(第2版) (2010)
  • Author(s): 細田洋司・寒川賢治
  • Total Pages: 776
• [Book] 日本臨床者増刊高血圧(第4版)上巻 (2009)
  • Author(s): 細田洋司・寒川賢治
  • Total Pages: 704