2011 Fiscal Year Final Research Report
The role of plasmin in the regulation of the multiple myeloma microenvironment
| Project/Area Number |
21591193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HEISSIG Beate 東京大学, 医科学研究所, 特任准教授 (30372931)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 酵素 / 細胞・組織 / 生体分子 / 凝固・線溶 |
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| Research Abstract |
One of the outside cellular regulators are metalloproteinases(MMPs). MMP activation can promote the secretion of hematopoietic growth factors, which in turn drive hematopoietic cell differentiation into e. g. CD11B-positive F4/80 BM-derived cells. These angiopotent cells can be recruited into various tumor beds to further accelerate vasuarization necessary for tumor growth. In addition, these BM-derived cells are major producers of MMPs, creating a vicious cycle accelerating tumor cell growth. In this application, I suggest that proteases can become a novel molecular target in the treatment of blood tumor-related disease treatment including myeloma.
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[Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+myeloid cell recruitment2012
Author(s)
Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K, Heissig B
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Journal Title
Leukemia
Volume: 26
Pages: 332-339
DOI
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[Journal Article] MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells2012
Author(s)
Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Yohei Morita, Makoto Nagano, Takeharu Sakamoto, Naohiko Koshikawa, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Motoharu Seiki, Hiromitsu Nakauchi, Koichi Hattori, and Beate Heissig
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Journal Title
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[Journal Article] Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice2012
Author(s)
Yoshihiko Tashiro, Chiemi Nishida, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Makoto Ishihara, Aki Sato, Ismael Gritli, Hiromitsu Komiyama, Yayoi Sato, Yuichi Tomiki, Hirokazu Sakamoto, Takashi Dan, Toshio Miyata, Ko Okumura, Hiromitsu Nakauchi, Koichi Hattori, and Beate Heissig
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Journal Title
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[Journal Article] Plasminogen deficiency attenuates post-natal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis2012
Author(s)
Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B
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Journal Title
Exp Hematol
Volume: Vol40
Pages: 143-154
DOI
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[Journal Article] Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration2010
Author(s)
Ohki M, Ohki Y, Ishihara M, Rosenkvist J, Gritli I, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Hattori K, Heissig B
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Journal Title
Blood
Volume: 115
Pages: 4302-4312
URL
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[Presentation] MT1-MMPRegulates Hematopoiesis Through HIF-Mediated2011
Author(s)
Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig and Koichi Hattori
Organizer
Chemo-/Cytokine Release From the Bone Marrow Niche 53回アメリカ血液学会
Place of Presentation
サンディエゴSan Diego Convention Center
Year and Date
20111210-13
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