2011 Fiscal Year Final Research Report
Combined Anti-Leukemia Therapy Targeting Constitutively Activated Tyrosine Kinases and Checkpoint Activation Mechanisms
| Project/Area Number |
21591194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIURA Osamu 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10209710)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血液腫瘍学 / 白血病 / 分子標的療法 |
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| Research Abstract |
Constitutively activated aberrant tyrosine kinases play important roles in development and evolution of hematopoietic malignancies and are also implicated in acquisition of therapy resistance. We found that the chemotherapy resistance of hematopoietic cells transformed by BCR/ABL, Flt3-ITD, or Jak2-V617F could be conquered by combining specific tyrosine kinase inhibitors against these aberrant kinases with DNA-damaging chemotherapeutic agents and elucidated the underlying molecular mechanisms.
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[Journal Article] Novel mouse xenograft models reveal a critical role of CD4+T cells in the proliferation of EBV-infected T and NK cells2011
Author(s)
Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, OhgaS, Nakamura H, Ito M, Miura O, KomanoJ, Fujiwara S
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Journal Title
PLoS Pathog
Volume: 7
Pages: e1002326
Peer Reviewed
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[Journal Article] Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement2010
Author(s)
Nakauchi Y, Takase H, Sugita S, Mochizuki M, Shibata S, Ishiwata Y, Shibuya Y, Yasuhara M, Miura O, AraiNakauchi Y, Takase H, Sugita S, Mochizuki M, Shibata S, Ishiwata Y, Shibuya Y, Yasuhara M, Miura O, Arai A
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Journal Title
Int J Hematol
Volume: 92
Pages: 179-185
Peer Reviewed
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