2011 Fiscal Year Final Research Report
Molecular mechanism of autophagy in follicular lymphoma cells
| Project/Area Number |
21591196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Fukui |
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Principal Investigator |
YOSHIDA Akira 福井大学, 医学部・附属病院, 講師 (80252005)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Bcl-2 / 濾胞性リンパ腫 / オートファジー |
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| Research Abstract |
We investigated the cell death mechanism of Bcl-2 over expressing human leukemia and lymphoma cells. We found that etoposide treatment increased Beclin-1 expression, the conversion of the soluble form of microtubule-associated protein 1 light chain 3(LC3) to the autophagic vesicle-associated form LC3-II and the occurence of lysosomes/autophagosomes in Bcl-2 over expressing cells. The autophagy inhibitor chloroquine enhanced the cytotoxicity of etoposide in Bcl-2 over expressing lymphoma cells. These data indicate that autophagy may play an important role as protective response after etoposide treatment.
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Research Products
(12 results)
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[Journal Article] Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line2010
Author(s)
Hosono, N., Kishi, S., Iho, S., Urasaki, Y., Yoshida, A., Kurooka, H., Yokota, Y., Ueda, T
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Journal Title
Cancer Sci.
Volume: 101(3)
Pages: 767-773
Peer Reviewed
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[Presentation] Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes2011
Author(s)
Yoshida, A. Zokumasu K., Yamauchi, T., Takagi, K., Kishi, S., Urasaki, Y., Tohyama, K., Ueda T.
Organizer
53rd American Society of Hematology Annual meeting
Place of Presentation
San Diego CA, USA
Year and Date
2011-12-12
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