Analysis of a role for BCR-ABL1 in the leukemogenesis using the experimental system that reflects the characteristics of human leukemia

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591200
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: KATAYAMA Naoyuki 三重大学, 大学院・医学系研究科, 教授 (20185812)
• Project Period (FY): 2009 – 2011
• Keywords: 血液腫瘍学 / 慢性骨髄性白血病 / 造血幹細胞 / BCR-ABL1遺伝子 / リンパ球分化

Research Abstract

We devised a unique culture system in which the developments of B cells and T cells as well as myeloid cells from human hematopoietic stem cells can be simultaneously evaluated. BCR-ABL1-transfected human CD34^+ cells showed the highly proliferative potential with different differentiation capacity from that of chronic myelogenous leukemia-derived cells. Monocytes in the peripheral blood proved to be immediate precursors of hepatic stellate cells of hematopoietic stem cell origin. It turned out that in acute type adult T cell leukemia/lymphoma, multiple subclones of common clone origin are present in the lymph nodes and a selected subclone exits into the peripheral blood.

Research Products

• [Journal Article] A case of three-year-old boy with severe haemophilia A on prophylaxis identified with a chronic subdural haematoma 2 years after the first episode of acute subdural bleeding (2012)
  • Author(s): Sakata K, Matsumoto T, Wada H, Katayama N
  • Journal Title: Haemophilia Volume: 18(1) Pages: e1-2
  • Peer Reviewed
• [Journal Article] IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells (2012)
  • Author(s): Suzuki K, Ono R, Ohishi K, Katayama N
  • Journal Title: Int J Oncol Volume: 40(1) Pages: 53-6
  • Peer Reviewed
• [Journal Article] Efficiency of diversion of the first aliquot of blood and prestorage leukoreducti-on for preventing bacterial contamination in red blood cell concentrates assessed using a rapid po-lymerase chain reaction-based bacterial detection system (2011)
  • Author(s): Nakamura A, Abe K, Masuya M, Katayama N
  • Journal Title: Transfusion Med Volume: 21(6) Pages: 365-370
  • Peer Reviewed
• [Journal Article] Ly6C+ monocytes are extrahepatic precursors of hepatic stellate cells in the injured liver of mice (2011)
  • Author(s): Masuya M, Nakamura S, Yukimoto H, Katayama N
  • Journal Title: Exp Hematol Volume: 39(9) Pages: 34-946
  • Peer Reviewed
• [Journal Article] Hepatic drug interaction between tacrolimus and lansoprazole in a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations (2011)
  • Author(s): Iwamoto T, Monma F, Fujieda A, Nakatani K, Katayama N, Okuda M
  • Journal Title: Clin Ther Volume: 33(8) Pages: 1077-1080
  • Peer Reviewed
• [Journal Article] CD5-positive diffuse large B-cell lymphoma : a retrospective study in 337 patients treated by chemotherapy with or without rituximab (2011)
  • Author(s): Miyazaki K, Yamaguchi M, Suzuki R, Katayama N
  • Journal Title: Ann Oncol Volume: 22(7) Pages: 1601-1607
  • Peer Reviewed
• [Journal Article] Clonal evolution of adult T-cell leukemia/lymphoma takes place in lymph node (2011)
  • Author(s): Umino A, Nakagawa M, Utsunomiya A, Katayama N
  • Journal Title: Blood Volume: 117(20) Pages: 5473-5478
  • Peer Reviewed
• [Journal Article] Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome (2011)
  • Author(s): Ito-Habe N, Wada H, Matsumoto T, Katayama N
  • Journal Title: Int J Hematol Volume: 93(1) Pages: 7-52
  • Peer Reviewed
• [Journal Article] Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation (2011)
  • Author(s): Takemitsu T, Wada H, Hatada T, Katayama N
  • Journal Title: Thromb Haemost Volume: 105(1) Pages: 40-44
  • Peer Reviewed
• [Journal Article] Correlation between imati-nib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia (2010)
  • Author(s): Takahashi N, Wakita H, Miura M, Katayama N
  • Journal Title: Clin Pharmacol The Volume: 88(6) Pages: 809-813
  • Peer Reviewed
• [Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis (2010)
  • Author(s): Liu B, Ohishi K, Yamamura K, Katayama N
  • Journal Title: Exp Hematol Volume: 38(8) Pages: 685-695
  • Peer Reviewed
• [Journal Article] Granzyme B is a novel interleukin-18 converting enzyme (2010)
  • Author(s): Omoto Y, Yamanaka K, Tokime K, Katayama N
  • Journal Title: J Dematol Sci Volume: 59(2) Pages: 129-135
  • Peer Reviewed
• [Journal Article] Drug interaction between itraconazole and bortezomib : exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib (2010)
  • Author(s): Iwamoto T, Ishibashi M, Fujieda A, Masuya M, Katayama N, Okuda M
  • Journal Title: Pharmacotherapy Volume: 30(7) Pages: 661-665
  • Peer Reviewed
• [Journal Article] Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia (2010)
  • Author(s): Nakamura A, Sugimoto Y, Ohishi K, Katayama N
  • Journal Title: J Clin Micribiol Volume: 48(6) Pages: 2030-203
  • Peer Reviewed
• [Journal Article] Elevated fibrin-related markers in patients with malignant diseases suspected of having thrombotic disorders (2010)
  • Author(s): Nomura H, Wada H, Mizuno T, Katayama N
  • Journal Title: Clin Appl Thromb Hemost Volume: 16(3) Pages: 266-272
  • Peer Reviewed
• [Journal Article] Fatal Trichosporon fungemia in patients with hematologic malignancies (2010)
  • Author(s): Suzuki K, Nakase K, Kyo T, Katayama N
  • Journal Title: Eur J Haematol Volume: 84(5) Pages: 441-447
  • Peer Reviewed
• [Journal Article] High-intensity signals in the basal ganglia from gadolinium-enhanced T1-weighted MRI as an early change in toxoplasma encephalitis in an AIDS patient (2010)
  • Author(s): Suzuki K, Masuya M, Matsumoto T, Ito N, Ohishi K, Maeda M, Katayama N
  • Journal Title: J Infect Chemother Volume: 16(2) Pages: 135-138
  • Peer Reviewed
• [Journal Article] Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation (2010)
  • Author(s): Torii M, Wang L, Ma N, Katayama N
  • Journal Title: Eur J Immunol Volume: 40(3) Pages: 787-79
  • Peer Reviewed
• [Journal Article] UV irradiation after immunizati-on induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10 (2010)
  • Author(s): Wang L, Saito K, Toda M, Katayama N
  • Journal Title: Immunobiology Volume: 215(2) Pages: 124-132
  • Peer Reviewed
• [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan(CHP)-NY-ESO-1 and CHP-HER2 with OK-432 (2009)
  • Author(s): Aoki M, Ueda S, Nishikawa H, Katayama N
  • Journal Title: Vaccine Volume: 27(49) Pages: 6854-6861
  • Peer Reviewed
• [Journal Article] Decreased ADAMTS13 levels in patients after living donor liver transplantation (2009)
  • Author(s): Kobayashi T, Wada H, Usui M, Katayama N
  • Journal Title: Thromb Res Volume: 124(5) Pages: 541-545
  • Peer Reviewed
• [Journal Article] Ease of early gastric cancer demarcation recognition : a compa-rison of four magnifying endoscopy methods (2009)
  • Author(s): Kadowaki S, Tanaka K, Toyoda H, Katayama N
  • Journal Title: J Gastroenterol Hepatol Volume: 24(10) Pages: 1625-1630
  • Peer Reviewed
• [Journal Article] The effectiveness of measuring for fragmented red cells using an automated hematology analyzer in patients with thrombotic microangiopathy (2009)
  • Author(s): Abe Y, Wada H, Yamada E, Katayama N
  • Journal Title: Clin Appl Thromb Hemost Volume: 15(3) Pages: 257-262
  • Peer Reviewed
• [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : a principal role for flt3 ligand in lymphopoiesis
  • Author(s): Nakamori Y, Liu B, Ohishi K, Katayama N
  • Journal Title: Br J Haematol Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Important role for flt3 ligand in the generation of early B and T cell precursors from human primitive hematopoietic progenitors, revealed by telomerized human stromal cells (2012)
  • Author(s): Liu B, Ohishi K, Masuya M, Hamada H, Katayama N
  • Organizer: 52^<nd> American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2012-12-05
• [Presentation] 同種造血幹細胞移植患者におけるタクロリムス薬物動態に対するチトクロムP450遺伝子多型の影響 (2012)
  • Author(s): 門間文彦、岩本卓也、中谷中、藤枝敦史、大石晃嗣、桝屋正浩、中瀬一則、奥田真弘、片山直之
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-25
• [Presentation] Evaluation of role for flt3L in human early B and T/NK lymphopoiesis in a nobel stromal cell culture system (2011)
  • Author(s): Nakamori Y, Ohishi K, Liu B, Masuya M, Hamada H, Katayama N
  • Organizer: 53^<rd> American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-12-11
• [Presentation] PCR analysis of bacteria and fungi in early phase of hematopoietic stem cell transplantation (2011)
  • Author(s): Fujieda A, Nakamura A, Ohishi K, Monma F, Masuya M, Nakase K, Matsushima Y, Wada H, Nobori T, Katayama N
  • Organizer: 53^<rd> American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-12-10
• [Presentation] Elevated plasma levels of von Willebrand factor propeptide in pat-ients with liver transplantation (2011)
  • Author(s): Habe N, Wada H, Matsumoto T, Ohishi K, Isaji S, Nobori T, Katayama N
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] CD5陽性びまん性大細胞型B細胞リンパ腫細胞で新たに確認された特徴的抗原発現 (2011)
  • Author(s): 横江香里、山口素子、宮崎香奈、小林恭子、片山直之
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] Gene expression profiling of diffuse large B-cell lymphomas supervised by CD5 expression (2011)
  • Author(s): Miyazaki K, Yamaguchi M, Kobayasshi K, Yokoe K, Imai H, Kobayashi T, Shiku H, Katayama N
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] DA-EPOCH-R療法および大量MTX療法で治療を行ったCD5陽性びまん性大細胞型B細胞リンパ腫 (2011)
  • Author(s): 景山裕紀、宮崎香奈、南博仁、小林恭子、藤枝敦史、山口素子、桝屋正浩、片山直之
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Novel molecular mechanism of MLL-mediated leukemogenesis via a self-renewal transcription factor (2011)
  • Author(s): Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Kamisako T, Ito M, Nakamura A, Suzuki K, Katayama N, Nosaka T
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Evaluation of role for flt3 ligand in human lymphopoiesis with telome-rized human stromal cells (2011)
  • Author(s): Nakamori Y, Ohishi K, Liu B, Masuya M, Hamada H, Katayama N
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Hematopoietic cells contribute to the generation of pancreatic stellate cells via MCP-1/CCR2 pathway (2011)
  • Author(s): Ino K, Masuya M, Nakamori Y, Suzuki K, Ohishi K, Katayama N
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Cytogenetic predictors of response to lenalidomide in patients with myeloid neoplasms without Del5q (2011)
  • Author(s): Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Andres J, Hadrian S, O' Keefe CL, Guinta K, Afable M, Tiu R, Mcgraw KR, List AF, Katayama N, Maciejewski J
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] In vivo persistence of adoptively transferred TCR genemodified lymphocytes in patients with advanced esophageal cancer (2011)
  • Author(s): Kageyama S, Ikeda H, Miyahara Y, Hori S, Saito K, Imai N, Okamoto S, Tomura D, Nukaya I, Mineno J, Takesako K, Katayama N, Shiku H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Gene expression profiling of diffuse large B-cell lymphomas supervised by CD5 expression. (2010)
  • Author(s): Miyazaki K, Yamaguchi M, Imai H, Tamaru S, Kobayashi T, Shiku H, Katayama N
  • Organizer: 52^<nd> American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2010-12-06
• [Presentation] Valproic acid results in maintenance but not expansion of transplantable hematopoietic stem cells from human umbilical cord blood (2010)
  • Author(s): Araki H, Baluchamy S, Petro B, Baig MS, Suhangul M, Quigley JG, Katayama N, Mahmud N
  • Organizer: 52^<nd> American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2010-12-06
• [Presentation] Array comparative genomic hybridization revealed polyclonality in acute type adult T-cell leukemia/lymphoma and PTCL NOS (2010)
  • Author(s): Umino A, Nakagawa M, Utsunomiya A, Tsukasaki K, Katayama N, Seto M
  • Organizer: 52^<nd> American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2010-12-05
• [Presentation] TMA患者におけるVWF propeptide値の検討 (2010)
  • Author(s): 波部尚美、和田英夫、登勉、片山直之
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] Prospective study on evaluation of DIC diagnostic criteria by three different diagnostic criteria (2010)
  • Author(s): Wada H, Matsumoto T, Ohishi K, Itoh-Habe N, Katayama N, Nobori T
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] Ikaros isoform 6 enhances proliferative effect by BCR-ABL1 in human CD34+ hematopoietic cells (2010)
  • Author(s): Suzuki K, Ono R, Ohishi K, Kataoka I, Masuya M, Hamadan H, Kitamura T, Katayama N, Nosaka T
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] Diagnostic value of granulocytosis for prediction of JAK2 mutation in polycythemic patients (2010)
  • Author(s): Ohishi K, Matsuo Y, Abe Y, Tamaki S, Usui E, Matsumoto T, Fujieda A, Miyazaki K, Kobayashi K, Monma F, Masuya M, Tamaru S, Nishikawa M, Nishioka J, Nobori T, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] BM CD34+ cells expanded on HUBEC reconstitutes lethally irradiated baboons in a variable manner (2010)
  • Author(s): Araki H, Mahmud N, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] A retrospective study of 31 patients with NK/T-cell lymphoma : Mie University Hospital experience (2010)
  • Author(s): Miyazaki K, Yamaguchi M, Ii N, Nomoto Y, Yuta A, Imai H, Masahiro Masuya M, Nakase K, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] CD5陽性びまん性大細胞型B細胞リンパ腫の新規治療開発に向けた免疫組織化学による各種抗原発現の検討 (2010)
  • Author(s): 江間菜々恵、山口素子、宮崎香奈、片山直之
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] 遺伝子組み換えトロンボモジュリン投与による各種凝血学的マーカーの変動 (2010)
  • Author(s): 松本剛史、和田英夫、鈴木彦次、岡宏次、渡邉泰行、上村泰弘、豊田秀実、塚田哲也、門間文彦、藤枝敦史、大石晃嗣、桝屋正浩、片山直之
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] PCR for detection of pathogenic bacteria in early phase of hematopoietic cell transplantation (2010)
  • Author(s): Fujieda A, Nakamura A, Ohishi K, Miyazaki K, Monma F, Matsumoto T, Yamaguchi M, Masuya M, Nakase K, Wada H, Nobori T, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Diagnostic utility of PCR analysis of bacteria and fungus from blood in febrile neutropenia (2010)
  • Author(s): Ohishi K, Nakamura A, Sugimoto Y, Sugawara Y, Fujieda A, Monma F, Masuya M, Nakase K, Matsushima K, Wada H, Nobori T, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Hematopoietic origin of pancreatic stellate cells (2010)
  • Author(s): Ino K, Masuya M, Miyata E, Ohishi K, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Crucial role of flt3 ligand in human early B/T lymphopoiesis revealed by telomerized stromal cells (2010)
  • Author(s): Liu B, Ohishi K, Suzuki K, Masuya M, Hamada H, Nishikawa H, Shiku H, Katayama N
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Evaluation of potential role for valproic acid in IL-3-mediated megaka-ryopoiesis and erythropoiesis in serum-free and serum-containing cultures (2009)
  • Author(s): Ohishi K, Liu B, Masuya M, Heike Y, Takaue Y, Katayama N
  • Organizer: 51^<st> American Society of Hematology Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2009-12-07
• [Presentation] Ly6C^+ inflammatory monocytes are extrahepatic precursors of hepatic stellate cells in liver injury (2009)
  • Author(s): Masuya M, Araki H, Ohishi K, Katayama N
  • Organizer: 51^<st> American Society of Hematology Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2009-12-06
• [Presentation] Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitutes lethally irradiated baboons in a variable manner (2009)
  • Author(s): Araki H, Chute J, Petro B, Katayama N, Hoffman R, Mahmud N
  • Organizer: 51^<st> American Society of Hematology Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2009-12-06
• [Presentation] Retrospective analysis of CD5+ DLBCL treated with chemotherapy with or without rituximab (2009)
  • Author(s): Miyazaki K, Yamaguchi M, Suzuki R, Kobayashi Y, Niitsu N, Ennishi D, Tamaru J-i, Ishizawa K, Kashimura M, Kagami Y, Sunami K, Yamane H, Nishikori M, Kosugi H, Yujiri T, Nakamura N, Masaki Y, Itoh K, Nawa Y, Hyo R, Sakai A, Tsukamoto N, Yano T, Katayama N, Kinoshita T, Nakamura S
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] 末梢性T細胞リンパ腫における遺伝子発現プロファイリング結果の免疫組織化学による検証 (2009)
  • Author(s): 山本麻里子、山口素子、宮崎香奈、片山直之
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Valproic acid, in com-bination with IL-3, stimulates human megakaryo-poiesis and erythropoiesis (2009)
  • Author(s): Liu B, Ohishi K, Masuya M, Heike Y, Takaue Y, Katayama N
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] 日本人慢性期CML314症例のイマチニブ血中濃度と治療効果:国内6研究グループのデーターの統合 (2009)
  • Author(s): 高橋直人、小笠原仁、波多野善明、北林淳、黒木淳、脇田久、石毛憲治、橋本真一郎、柏村眞、藤川一壽、深沢元晴、片山俊夫、西井一浩、門間文彦、劉冰、片山直之、増子正義、成田美和子、古川達雄、境麻里、宮崎泰司、前田裕弘、浦瀬文明、澤田賢一
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] MLL-ENL融合遺伝子は造血幹細胞のみを標的として形質転換を生じる (2009)
  • Author(s): 小埜良一、桝屋正浩、宮田恵里、中島秀明、上迫努、伊藤守、鈴木圭、片山直之、北村俊雄、野阪哲哉
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Monocytic origin of hepatic stellate cells in liver injury (2009)
  • Author(s): Masuya M, Nakamura S, Miyata E, Araki H, Ohishi K, Katayama N
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Epigenetic regulation of ex-vivo expansion of HSC remains permissive to external environmental cues (2009)
  • Author(s): Araki H, Mahmud N, Katayama N
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-23
• [Presentation] Ly6C^+単球は肝傷害時の肝星細胞の前駆細胞である (2009)
  • Author(s): 桝屋正浩、大石晃嗣、片山直之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-03
• [Presentation] アレイCGHにより明らかになった急性型ATLの多クローン性 (2009)
  • Author(s): 海野啓、中川雅夫、宇都宮與、塚崎邦弘、片山直之、瀬戸加大
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-03
• [Presentation] 乳癌術前化学療法によるHER2発現変化の検討 (2009)
  • Author(s): 齋藤佳菜子、水野聡朗、北野滋久、山下芳樹、影山慎一、小川朋子、白石泰三、片山直之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-02
• [Presentation] HDAC阻害剤は、IL-3やGM-CSF存在下での巨核球系あるいは赤芽球系造血を促進する (2009)
  • Author(s): 大石晃嗣、平家勇司、高上洋一、片山直之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-02
• [Presentation] MLL-ENL融合遺伝子による形質転換は造血幹細胞のみを標的として生じる (2009)
  • Author(s): 小埜良一、桝屋正浩、宮田恵里、中島秀明、上迫努、伊藤守、鈴木圭、片山直之、北村俊雄、野阪哲哉
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-01
• [Book] 白血病・リンパ腫・骨髄腫-今日の診断と治療 (2011)
  • Author(s): 片山直之
  • Total Pages: 302-310
  • Publisher: 中外医学社
• [Book] 専門医のための薬物療法Q & A血液 (2011)
  • Author(s): 藤枝敦史、片山直之
  • Total Pages: 306-311
  • Publisher: 中外医学社
• [Book] 今日の治療指針2011、赤芽球瘻 (2011)
  • Author(s): 片山直之
  • Total Pages: 585-586
  • Publisher: 医学書院
• [Book] 症候群ハンドブック、2011、ガードナー・ダイアモンド症候群 (2010)
  • Author(s): 片山直之
  • Total Pages: 311-331
  • Publisher: 中山書店
• [Book] 血液疾患最新の治療2011-2013、巨赤芽球性貧血 (2010)
  • Author(s): 片山直之
  • Total Pages: 108-110
  • Publisher: 南江堂
• [Book] 今日の治療指針2010、真性赤血球増加症、本態性血小板血症、原発性骨髄線維症 (2010)
  • Author(s): 片山直之
  • Total Pages: 539-541
  • Publisher: 医学書院
• [Book] EBM血液疾患の治療、MDSに対する免疫抑制療法の適応と方法は? (2009)
  • Author(s): 片山直之、中森良樹
  • Total Pages: 57-61
  • Publisher: 中外医学社
• [Book] 血液内科ベッドサイドメモ (2009)
  • Author(s): 片山直之
  • Total Pages: 366
  • Publisher: 中外医学社