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2011 Fiscal Year Final Research Report

Establishment of new classification in myeloid neoplasms for personalized medicine

Research Project

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Project/Area Number 21591206
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionHiroshima University

Principal Investigator

HARADA Hironori  広島大学, 原爆放射線医科学研究所, 講師 (10314775)

Co-Investigator(Kenkyū-buntansha) HARADA Yuka  広島大学, 原爆放射線医科学研究所, 助教 (50379848)
Project Period (FY) 2009 – 2011
Keywords骨髄球系造血器腫瘍 / 骨髄異形成症候群 / 遺伝子変異 / 転写因子 / RUNX1遺伝子変異 / GATA2遺伝子変異 / BMI1 / ヒト造血幹細胞
Research Abstract

We analyzed gene abnormalities that may play a central role for the pathogenesis in myelodysplastic syndromes(MDS) and acute myeloid leukemias. Gene mutations of hematopoietic transcriptional factors RUNX1, CEBPA and GATA2 have been detected. Moreover, we clarified that the mutants had a potential to develop MDS by using human hematopoietic stem cells and mouse bone marrow transplantation model. Therefore, we proposed that the mutations of RUNX1, CEBPA and GATA2 are the master gene mutations for the pathogenesis of MDS.

  • Research Products

    (73 results)

All 2012 2011 2010 2009

All Journal Article (30 results) (of which Peer Reviewed: 15 results) Presentation (39 results) Book (4 results)

  • [Journal Article] Morphologic analysis in myelodysplastic syndromes with del(5q) treated with lenalidomide2012

    • Author(s)
      Matsuda A, Taniwaki M, Jinnai I, HaradaH, Watanabe M, Suzuki K, Yanagita S, SuzukiT, Yoshida Y, Kimura A, Tsudo M, TohyamaK, Takatoku M, Ozawa K
    • Journal Title

      A Japanese multi-institutional study. LeukRes

      Volume: 36(5) Pages: 575-580

    • Peer Reviewed
  • [Journal Article] C-terminal mutation of RUNX1 attenuates the DNA-damage repairresponse in hematopoietic stem cells.2012

    • Author(s)
      Satoh Y, Matsumura I, Tanaka H, HaradaH, Harada Y, Matsui K, Shibata M, MizukiM, Kanakura Y
    • Journal Title

      Leukemia

      Volume: 26(2) Pages: 303-311

    • Peer Reviewed
  • [Journal Article] Fynis not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models2012

    • Author(s)
      Doki N, Kitaura J, Inoue D, Kato N, Kagiyama Y, Uchida T, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Oki T, HaradaY, Nakahara F, Harada H, Kitamura T
    • Journal Title

      Int J Hematol

      Volume: 95(2) Pages: 167-175

    • Peer Reviewed
  • [Journal Article] 造血器腫瘍におけるEZH2変異とその機能的意義[特集:造血器腫瘍の新たな分子病態とその臨床的意義]2012

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      血液内科

      Volume: 64(2) Pages: 139-144

  • [Journal Article] Good' ssyndrome-associated pure red cell aplasia with myelodysplastic syndrome2011

    • Author(s)
      Nitta H, Harada Y, Okikawa Y, Fujii M, Arihiro K, Kimura A, Harada
    • Journal Title

      Intern Med

      Volume: 50(18) Pages: 2011-2014

    • Peer Reviewed
  • [Journal Article] Molecularmechanisms that produce secondary MDS/ AMLby RUNX1/ AML1 point mutations2011

    • Author(s)
      Harada Y, Harada H
    • Journal Title

      J Cell Biochem

      Volume: 112 Pages: 425-432

    • Peer Reviewed
  • [Journal Article] Two typesof C/ EBP mutations play distinct but collaborative roles in leukemogenesis2011

    • Author(s)
      Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, Kitamura T
    • Journal Title

      lessons from clinical data and BMT models. Blood

      Volume: 117 Pages: 221-233

    • Peer Reviewed
  • [Journal Article] 放射線発がん(骨髄異形成症候群・白血病)の分子病態.特集「放射線の人体影響~原爆・チェルノブイリの知見とフクシマ~」.2011

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      血液フロンティア

      Volume: 21(12) Pages: 1775-1781

  • [Journal Article] MPNと遺伝.特集2011

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      骨髄増殖性腫瘍(MPN)の最新の進歩.最新医学

      Volume: 66(11) Pages: 2552-2557

  • [Journal Article] MDS「分子病態」2011

    • Author(s)
      原田浩徳
    • Journal Title

      第73回日本血液学会学術集会教育講演特集号.臨床血液

      Volume: 52 Pages: 1525-1534

  • [Journal Article] [解説]APL治療後の二次性骨髄性腫瘍とその特徴2011

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      血液内科

      Volume: 63 Pages: 382-388

  • [Journal Article] 12.原田結花,今川潤,原田浩徳:メチル化阻害剤の作用機構2011

    • Author(s)
      原田結花, 今川潤, 原田浩徳
    • Journal Title

      血液フロンティア

      Volume: 21 Pages: 1291-1298

  • [Journal Article] ダサチニブ少量療法が有効であったイマチニブ不耐容慢性好酸球性白血病2011

    • Author(s)
      今川潤, 原田結花, 吉田徹巳, 樽谷美保, 木村昭郎, 松元加奈, 森田邦彦, 原田浩徳
    • Journal Title

      臨床血液

      Volume: 52(7) Pages: 546-550

    • Peer Reviewed
  • [Journal Article] Clinical and genetic features oftherapy-related myeloid neoplasms after chemotherapy for acute promyelocytic leukemia.2010

    • Author(s)
      Imagawa J, Harada Y, Shimomura T, Tanaka H, Okikawa Y, Hyodo H, Kimura A, Harada H
    • Journal Title

      Blood

      Volume: 116 Pages: 6018-6022

    • Peer Reviewed
  • [Journal Article] Giant granulocytic sarcoma of the vagina concurrent with acute myeloid leukemiawith t(8 ; 21)(q22 ; q22) translocation.2010

    • Author(s)
      Imagawa J, Harada Y, Yoshida T, SakaiA, Sasaki N, Kimura A, Harada H
    • Journal Title

      Int J Hematol

      Volume: 92(3) Pages: 553-555

    • Peer Reviewed
  • [Journal Article] AID-inducedT-lymphoma or B-leukemia/ lymphoma in amouse BMT model.2010

    • Author(s)
      Komeno Y, Kitaura J, Watanabe-OkochiN, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, HayashiY, Honjo T, Kitamura T
    • Journal Title

      Leukemia

      Volume: 24(5) Pages: 1018-1024

    • Peer Reviewed
  • [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transitionin chronic myelogenous leukemia2010

    • Author(s)
      Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
    • Journal Title

      Blood

      Volume: 115(14) Pages: 2872-2881

    • Peer Reviewed
  • [Journal Article] C/ EBPα変異パターンによる急性骨髄性白血病(AML)および骨髄異形成症候群(MDS)病型の解析.2010

    • Author(s)
      原田浩徳, 今川潤, 原田結花, 木村昭郎
    • Journal Title

      広島医学

      Volume: 63(4) Pages: 311-313

  • [Journal Article] DNAメチル化阻害剤~急性骨髄性白血病に対する効果~.別冊血液フロンティア「血液疾患における分子標的治療ドラッグラグ解消に向けて」I.白血病.2010

    • Author(s)
      今川潤, 原田浩徳
    • Journal Title

      企画:黒川峰夫.大阪,医薬ジャーナル社

      Pages: 1513-1519

  • [Journal Article] レナリドミド~骨髄異形成症候群の治療~.別冊血液フロンティア「血液疾患における分子標的治療ドラッグラグ解消に向けて」IV.骨髄異形成症候群2010

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      企画:大屋敷一馬.大阪,医薬ジャーナル社

      Pages: 1733-1740

  • [Journal Article] MDSに対するレナリドミド治療とその感受性因子2010

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      血液・腫瘍科

      Volume: 61 Pages: 690-698

  • [Journal Article] TET2と骨髄性腫瘍.2010

    • Author(s)
      原田浩徳, 原田結花
    • Journal Title

      TET2と骨髄性腫瘍

      Volume: 20 Pages: 1902-1906

  • [Journal Article] 骨髄増殖性腫瘍における白血病移行の分子機構2010

    • Author(s)
      原田結花, 原田浩徳
    • Journal Title

      血液・腫瘍科

      Volume: 61 Pages: 143-150

  • [Journal Article] [解説]骨髄異形成症候群とレナリドミド―日本における成績.2010

    • Author(s)
      原田浩徳
    • Journal Title

      血液・腫瘍科

      Volume: 60(3) Pages: 348-355

  • [Journal Article] AML1/ RUNX1 point mutation possibly promotes leukemic transformation in myelodysplastic neoplasms2009

    • Author(s)
      Ding Y, Harada Y, Imagawa J, Kimura A, Harada H
    • Journal Title

      Blood

      Volume: 114(25) Pages: 5201-5205

    • Peer Reviewed
  • [Journal Article] Lenalidomide is active in Japanesepatients with symptomatic anemia in low-or Intermediate I risk myelodysplastic syndrome(MDS) with a deletion 5qabnormality2009

    • Author(s)
      Harada H, Watanabe M, Suzuki K, Yamagata S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M, Ozawa K
    • Journal Title

      Int J Hematol

      Volume: 90(3) Pages: 353-360

    • Peer Reviewed
  • [Journal Article] Possible involvement of RasGRP4 in leukemogenesis2009

    • Author(s)
      Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, KitauraJ, Kitamura T
    • Journal Title

      Int J Hematol

      Volume: 89(4) Pages: 470-481

    • Peer Reviewed
  • [Journal Article] Molecular pathways mediating MDS/ AML with focus on AML1/ RUNX1point mutations2009

    • Author(s)
      Harada Y, Harada H
    • Journal Title

      J Cell Physiol

      Volume: 220 Pages: 16-20

    • Peer Reviewed
  • [Journal Article] 被ばくMDS/ AMLの分子発症メカニズム2009

    • Author(s)
      原田結花, 原田浩徳, 川野徳幸, 木村昭郎
    • Journal Title

      放射線生物研究

      Volume: 44(4) Pages: 431-446

  • [Journal Article] その他の骨髄増殖性疾患と骨髄異形成症候群2009

    • Author(s)
      原田浩徳, 原田結花, 木村昭郎
    • Journal Title

      日本臨牀

      Volume: 67(10) Pages: 1901-1905

  • [Presentation] 造血器腫瘍におけるRUNX1, MLLキメラ遺伝子発生プロセスの解明2012

    • Author(s)
      原田浩徳, 原田結花
    • Organizer
      第16回造血器腫瘍研究会
    • Place of Presentation
      東京
    • Year and Date
      20120128-29
  • [Presentation] RUNX1変異を中心としたMDSの分子病態2012

    • Author(s)
      原田浩徳
    • Organizer
      血液腫瘍シンポジウム2012MDS~病態解析と治療の進歩~
    • Place of Presentation
      東京
    • Year and Date
      2012-03-03
  • [Presentation] Expansion of CD8+/ perforin+ T-cell subset in patients predictsresponse to cyclosporin a therapy inpatients with erythroid hypoplasia/ aplasia2011

    • Author(s)
      Nitta H, Harada Y, Hyodo H, Kimura A, Harada H
    • Organizer
      53rd Annual Meeting of theAmerican Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20111210-13
  • [Presentation] BMI1 collaborates withRUNX1/ AML1 mutants in the development ofhuman myelodysplastic syndrome(MDS)/ acute myeloid leukemia(AML)2011

    • Author(s)
      Harada H, Ding Y, Imagawa J, Miyama T, Kimura A, Harada Y
    • Organizer
      53rd AnnualMeeting of the American Society ofHematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20111210-13
  • [Presentation] Molecular mechanisms thatproduce radiation-induced or therapyrelatedMDS/ AML by RUNX1/ AML1 pointmutations2011

    • Author(s)
      Harada H
    • Organizer
      The 6th InternationalSymposium of Nagasaki University GlobalCOE Program" Global Strategic Center forRadiation Health Risk Control
    • Place of Presentation
      Nagasaki
    • Year and Date
      20111020-22
  • [Presentation] The dynamic effect of dasatinib on largegranular lymphocyte expansion in Ph ALLpatient2011

    • Author(s)
      Imagawa J, Yoshida T, Mino T, Kimura A, Matsumoto K, Morita K, Harada Y, Harada H
    • Organizer
      73rd Annual Meeting of theJapanese Society of Hematology
    • Place of Presentation
      Nagoya
    • Year and Date
      20111014-16
  • [Presentation] Deferasirox improved cytopenia inpatients with bone marrow failure2011

    • Author(s)
      Harada Y, Okikawa Y, Kimura A, Ito T, Niimi H, Noda M, Tanaka H, Shimomura T, Kuroda Y, Katsutani S, Kimura A, Harada H
    • Organizer
      73rdAnnual Meeting of the Japanese Society ofHematology
    • Place of Presentation
      Nagoya
    • Year and Date
      20111014-16
  • [Presentation] Myelodysplastic syndrome with pure redcell aplasia, clinical new entity2011

    • Author(s)
      Nitta H, Harada Y, Kimura A, Harada H
    • Organizer
      73rdAnnual Meeting of the Japanese Society ofHematolog
    • Place of Presentation
      Nagoya
    • Year and Date
      20111014-16
  • [Presentation] Molecular mechanisms to produced myeloidneoplasms by RUNX1 or MLL chimeras in humanCD34+ cells2011

    • Author(s)
      Harada H, Ding Y, Kimura A, Harada Y
    • Organizer
      73rd Annual Meeting of theJapanese Society of Hematology
    • Place of Presentation
      Nagoya
    • Year and Date
      20111014-16
  • [Presentation] Long-term follow up data of cytogeneticresponse in Japanese low/ lnt-1 MDSpatients with del(5q)2011

    • Author(s)
      Taniwaki M, Chinen Y, Harada H, Watanabe M, Suzuki K, Yanagida S, ShimadaH, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Matsuda A, Tohyama K, Takatoku M, Ozawa K
    • Organizer
      The 73rd AnnualMeeting of the Japanese Society ofHematology
    • Place of Presentation
      Nagoya
    • Year and Date
      20111014-16
  • [Presentation] 教育講演MDS「分子病態」2011

    • Author(s)
      原田浩徳
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20111014-16
  • [Presentation] Molecularmechanism to produce myeloid neoplasms byRUNX1 or MLL chimeras in human CD34+ cells2011

    • Author(s)
      Harada H, Harada Y
    • Organizer
      The 18th International RUNX Workshop
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20110814-17
  • [Presentation] RUNX1変異によるMDSの分子発症メカニズム2011

    • Author(s)
      原田浩徳
    • Organizer
      2011新学術領域細胞運命制御班会議
    • Place of Presentation
      軽井沢
    • Year and Date
      20110531-0602
  • [Presentation] Clinical and Genetic Features of Therapy-Related Myeloid Neoplasms after Chemotherapy for Acute Promyelocy ticleukemia.2011

    • Author(s)
      Imagawa J, Harada Y, Kimura A, Harada H
    • Organizer
      The 2nd JSH International Symposium 2011 in Nagasaki
    • Place of Presentation
      Nagasaki
    • Year and Date
      20110423-24
  • [Presentation] 骨髄異形成症候群(MDS)の最近の知見~発症機序と治療を中心に~2011

    • Author(s)
      原田浩徳
    • Organizer
      第165回福岡血液懇話会
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-08
  • [Presentation] 放射線・化学療法関連骨髄系腫瘍の発症に関わるRUNX1/ AML1遺伝子点突然変異2011

    • Author(s)
      原田結花, 木村昭郎, 原田浩徳
    • Organizer
      第52回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Year and Date
      2011-06-05
  • [Presentation] RUNX1のC末部変異体によるMDS/ AML分子発症機構2011

    • Author(s)
      原田浩徳
    • Organizer
      第7回広島大学・長崎大学連携研究事業カンファランス
    • Place of Presentation
      広島
    • Year and Date
      2011-06-04
  • [Presentation] 放射線関連MDS・白血病の発症機序におけるAML1点突然変異の役割.2010

    • Author(s)
      原田浩徳
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Year and Date
      20101020-22
  • [Presentation] Molecular mechanisms to produce MDS/ AMLby C-terminal trancated type of AML1/ RUNX1mutations.2010

    • Author(s)
      Harada H, Harada Y, Imagawa J, Kimura A
    • Organizer
      72nd Annual Meeting of JapaneseSociety of Hematology
    • Place of Presentation
      Yokohama
    • Year and Date
      20100924-26
  • [Presentation] Successful 2nd CBT using minimalconditioning regimens for patients withprimary graft failure2010

    • Author(s)
      Okikawa Y, Kuroda Y, Ito T, Niimi H, Harada H
    • Organizer
      72nd Annual Meetingof Japanese Society of Hematology
    • Place of Presentation
      Yokohama
    • Year and Date
      20100924-26
  • [Presentation] Deferasirox improved severe cardiacinsufficiency and pancytopenia in apatient with aplastic anemia2010

    • Author(s)
      Harada Y, Harada H, Imagawa J, KimuraA
    • Organizer
      72nd AnnualMeeting of Japanese Society of Hematology
    • Place of Presentation
      Yokohama
    • Year and Date
      20100924-26
  • [Presentation] A vaginalgiant granulocytic sarcoma concurrentlywith acute myeloid leukemia witht(8 ; 21)(q22 ; q22).2010

    • Author(s)
      Imagawa J, Harada H, Yoshida T, SakaiA, Harada Y, Sasaki N, Kimura A
    • Organizer
      72nd Annual Meeting ofJapanese Society of Hematology
    • Place of Presentation
      Yokohama
    • Year and Date
      20100924-26
  • [Presentation] A caseof FPD/ AML with a novel RUNX1 mutation2010

    • Author(s)
      Sakurai M, Watanabe N, Harada H, HaradaY, Sadahira K, Fukuchi Y, Tsukada Y, Yokoyama K, Okamoto S, Nakajima H
    • Organizer
      72nd Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Yokohama
    • Year and Date
      20100924-26
  • [Presentation] Molecularmechanism to produce MDS/ AML by C-terminal truncated type of AML1/ RUNX1 mutations.2010

    • Author(s)
      Harada H, Harada Y
    • Organizer
      The 17th International RUNX Workshop
    • Place of Presentation
      Hiroshima
    • Year and Date
      20100711-14
  • [Presentation] 骨髄増殖性腫瘍からの白血病移行メカニズムの解明2010

    • Author(s)
      丁曄, 原田結花, 今川潤, 木村昭郎, 原田浩徳
    • Organizer
      第107回日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      20100409-11
  • [Presentation] 慢性骨髄増殖性腫瘍からの白血病移行メカニズムの解明2010

    • Author(s)
      丁曄, 原田結花, 原田浩徳
    • Organizer
      第6回麒麟塾
    • Place of Presentation
      東京
    • Year and Date
      2010-06-05
  • [Presentation] Effects of radiation onhematopoietic organ. Myelodysplasticsyndrome caused by radiation after longlatency period2009

    • Author(s)
      Harada H
    • Organizer
      International Workshop on Chernobyl Health Consequences
    • Place of Presentation
      Kiev, Ukraine
    • Year and Date
      20091215-17
  • [Presentation] AML1/ RUNX1 point mutationpossibly promotes leukemic transformationin chronic myeloproliferative disorders2009

    • Author(s)
      Imagawa J, Harada Y, Ding Y, Kimura A, Harada H
    • Organizer
      51st American Society of Hematology annualmeeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      20091205-08
  • [Presentation] C-terminalmutation of RUNX1 deteriorates DNAdamage-repair response and promotes thedevelopment of acute myeloid leukemia2009

    • Author(s)
      Satoh Y, Matsumura I, Tanaka H, HaradaH, Harada Y, Kanakura Y
    • Organizer
      51st American Society of Hematology annualmeeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      20091205-08
  • [Presentation] Analysis of C/ EBPA mutationsin AML, MDS by a mouse BMT model2009

    • Author(s)
      Kato N, Komeno Y, Watanabe N, NakaharaF, Doki N, Harada H, Harada Y, Kitaura J, Kitamura T
    • Organizer
      71stAnnual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Kyoto
    • Year and Date
      20091023-25
  • [Presentation] RUNX1 controls nucleotide excision repair(NER) throughtranscriptional regulation of Gadd45a.2009

    • Author(s)
      Satoh Y, Matsumura I, Harada H, HaradaY, Kanakura Y
    • Organizer
      71st Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Kyoto
    • Year and Date
      20091023-25
  • [Presentation] Lenalidomide inJapanese Patients with Symptomatic anemiain Low or Int-1 Risk MDS with deletion 5q.2009

    • Author(s)
      Watanabe M, Harada H, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Tsudo M, Kimura A, Matsuda A, Tohyama K, TaniwakiM, Takatoku M, Ozawa K
    • Organizer
      71st Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Kyoto
    • Year and Date
      20091023-25
  • [Presentation] Distinct molecular pathways andclinical features of MDS/ AML by twodifferent AML1 mutants.2009

    • Author(s)
      Harada H, Harada Y, Imagawa J, Kimura A
    • Organizer
      71st Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Kyoto
    • Year and Date
      20091023-25
  • [Presentation] RUNX1 controls nucleotideexcision repair(NER) throughtran scriptional regulation of Gadd45a.2009

    • Author(s)
      Satoh Y, Matsumura I, Harada H, Kanakura Y
    • Organizer
      68th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      20091001-03
  • [Presentation] Two different AML1mutants expressed in human CD34+ cellsexhibit distinct molecular pathways andclinical features of MDS/ AML2009

    • Author(s)
      Harada H, Harada Y
    • Organizer
      EMBO Workshop(16th RUNX Meeting)
    • Place of Presentation
      Oxford, UK
    • Year and Date
      20090816-19
  • [Presentation] AML1/ RUNX1point mutation possibly promotes leukemictrans for mation in chronic myeloproliferativedisorders2009

    • Author(s)
      Harada Y, Ding Y, Harada H
    • Organizer
      EMBO Workshop(16th RUNX Meeting)
    • Place of Presentation
      Oxford, UK
    • Year and Date
      20090816-19
  • [Presentation] Results ofPhase II Clinical Study of Lenalidomide in Japanese Patients with Myelodysplastic Syndrome(MDS)2009

    • Author(s)
      Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Takatoku M, Ozawa K
    • Organizer
      The 10th InternationalSymposium on Myelodysplastic Syndromes(MDS2009)
    • Place of Presentation
      Patras, Greece
    • Year and Date
      20090506-09
  • [Presentation] 日本人の骨髄異形成症候群(MDS)患者を対象としたlenalidomideの第II相臨床試験成績2009

    • Author(s)
      渡邊光正, 通堂満, 鈴木憲史, 原田浩徳, 木村昭郎, 柳田宗之, 鈴木隆浩, 吉田彌太郎, 高徳正昭, 小澤敬也
    • Organizer
      第106回日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      20090410-12
  • [Presentation] C/ EBPα変異パターンによる急性骨髄性白血病(AML)および骨髄異形成症候群(MDS)病型の解析2009

    • Author(s)
      原田浩徳, 今川潤, 原田結花, 木村昭郎
    • Organizer
      第50回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-06-07
  • [Book] A New Challenge ofRadiation Health Risk Molecularmechanisms that produce radiation-inducedor therapy-related MDS/ AML by RUNX1/ AML1point mutations, Management. Nakashima M, Takamura N, Suzuki K, Yamashita S(Eds.)2012

    • Author(s)
      Harada H, Harada Y
    • Total Pages
      151-160
  • [Book] 骨髄性白血病の発症機構.I章.造血システムと腫瘍化」血液専門医テキスト2011

    • Author(s)
      原田結花,原田浩徳
    • Total Pages
      10-14
    • Publisher
      日本血液学会編
  • [Book] 治療レナリドミド.骨髄異形成症候群(MDS)診療up-to-date2011

    • Author(s)
      原田結花,原田浩徳
    • Total Pages
      135-151
    • Publisher
      中外医学社
  • [Book] 治療関連白血病の予後・治療法2009

    • Author(s)
      原田浩徳,原田結花
    • Total Pages
      334-336
    • Publisher
      中外医学社

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Published: 2013-07-31  

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