2011 Fiscal Year Final Research Report
A whole genomic analysis of acute myeloid leukemia.
| Project/Area Number |
21591217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 急性骨髄性白血病 / Blast Bank / ゲノムリシークエンス |
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| Research Abstract |
Leukemias are clonal disorders of hematopoietic stem cells or immature progenitors. However, a simple comparison of the bone marrow(BM) mononuclear cells(MNCs) among heterogeneous acute myeloid leukemia(AML) patients is likely to reveal a large number of changes in the genome that reflect differences either in the percentage of blasts within BM, or in the differentiation ability of the blasts. To minimize such population-shift effects, we have set up a large-scale cell bank(the Blast Bank) for the storage of hematopoietic stem cell(HSC)-like fractions purified from individuals with a wide range of leukemic disorders. To identify oncogenes in leukemias, and to clarify a molecular signature that was directly linked to the prognosis of leukemic patients, we performed a large-scale genomic analysis of the Blast Bank specimens.
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Research Products
(16 results)
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[Presentation] Array-based genomic resequencing of acute myeloid leukemia2011
Author(s)
Yamashita, Y., Ueno, T., Soda, M., Mano, H.
Organizer
Cold Spring Harbor Asia Conference, Translational Approaches to Cancer
Place of Presentation
Victoria, Suzhou, Jiangsu Province, China
Year and Date
20110524-28
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[Presentation] Array-based genomic resequencing of acute myeloid leukemia2010
Author(s)
Yamashita, Y., Soda, M., Ueno, T., Mano, H.
Organizer
Keystone Symposia, New Paradigms in Cancer Therapeutics, Victoria, British Columbia
Place of Presentation
Canada
Year and Date
20100323-28
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