2011 Fiscal Year Final Research Report
Analysis of the mechanism of L-asparaginase to suppress the highly expressed eIF4E in NK-cell lymphoma
| Project/Area Number |
21591222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Hiroshi 東京大学, 大学院・医学系研究科, 特任助教 (00587793)
FUJIMURA Tsutomu 順天堂大学, 医学系, 准教授 (70245778)
TAKAGI Masatoshi 東京医科歯科大学, 医歯学総合研究科, 講師 (10406267)
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| Project Period (FY) |
2009 – 2011
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| Keywords | L-asparaginase / NK細胞リンパ腫 / eIF4E / グルタミン / TCAサイクル |
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| Research Abstract |
We have shown two new mechanism of L-asparaginase(L-ASP), which is efficient even for chemotherapy-resistant NK-cell lymphoma. First, L-ASP decreased expression levels of various translation initiation factors including eIF4E, which in turn suppressed the translation of MYC, BCL-2 and eIF4E itself with tumor promoting and apoptosis inhibiting activities. Second, L-ASP depleted glutamine, induced TCA cycle depletion and insufficiency, and finally caused apoptosis. The result showed glutamine addiction of various lymphoid malignancies including acute lymphoblastic leukemia and the central role of TCA cycle in the suppression of apoptosis.
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Research Products
(16 results)
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[Journal Article] Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of epstein-barr virus infection2011
Author(s)
Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada JI, Fujiwara S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H
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Journal Title
Int J Cancer
Volume: 129
Pages: 2263-2273
Peer Reviewed
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