2011 Fiscal Year Final Research Report
Genetic abnormality require their specific differentiation stage in leukemogenensis
| Project/Area Number |
21591224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
YAHATA Takashi 東海大学, 医学部, 講師 (10398753)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 急性骨髄性白血病 / class I異常 / class II異常 / ヒト臍帯血CD34陽性細胞 / NOGマウス |
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| Research Abstract |
This study aimed to see whether human hematopoietic cells harboring these genetic abnormalities cause AML in immunodeficient mice. When FLT3-ITD as a class I mutation and PML-RARA mutant as a class II mutation were applied, leukemia occurred regardless of co-transduction of FLT3-ITD. The leukemia recapitulated human acute promyelocytic leukemia phenotypically and genetically, suggesting this is a good in vivo model for analyzing APL pathogenesis.
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[Journal Article] Establishment of xenograft model of human myelodysplastic syndromes2011
Author(s)
Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
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Journal Title
Haematologica
Volume: Vol.96, No.4
Pages: 543-551
Peer Reviewed
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[Journal Article] 臍帯血バンクの検査から判明した一過性異常骨髄増殖症2010
Author(s)
峯尾和美, 田中由美子, 田中雄三, 権藤和美, 川田勉, 佐藤薫, 加藤俊一, 松下弘道, 矢部みはる, 宮地勇人
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Journal Title
日検血会誌
Volume: Vol.11, No.1
Pages: 34-38
Peer Reviewed
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[Journal Article] Clinical and pathological features of B-cell non-Hodgkin lymphomas lacking the surface expression of immuneglobulin light chains
Author(s)
Matsushita H, Nakamura N, Tanaka Y, Ohgiya D, Tanaka Y, Damdinsuren A, Asai S, Yabe M, Kawada H, Ogawa Y, Ando K, Miyachi H
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Journal Title
Clin Chem Lab Med
Volume: (in press)
Peer Reviewed
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[Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA2011
Author(s)
Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Satou T, Tanaka M, Hayashi H, Miyachi H, Ando K
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2011-10-16
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