2011 Fiscal Year Final Research Report
The Role of Reactive Oxygen Species In Apoptosis Induction of Mantle Cell Lymphoma(MCL); Inhibition of NADPH Oxidase 2 Induces Apoptosis In MCL
| Project/Area Number |
21591226
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
MIURA Yuji 愛知医科大学, 看護学部, 教授 (00345612)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIWA Hroshi 愛知医科大学, 医学部, 教授 (00209967)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 悪性リンパ腫 / ストローマ / 薬剤耐性 |
|---|
| Research Abstract |
Mantle cell lymphoma(MCL) is an aggressive tumor and is characterized by deregulated growth and resistance to apoptosis. Reactive oxygen species(ROS) are important signal transduction molecules in regulation of MCL cell growth, differentiation and apoptosis. ROS generated by Nox2, at least in part, transmit cell survival signals through the AKT-ASK1 pathway in MCL cells and their depletion leads to apoptosis.
|
