Establishment of optimal hematopoietic stem cell transplantation donor selection based on analysis of immune-related gene polymorphism

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591236
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kanazawa University
• Principal Investigator: TAKAMI Akiyoshi 金沢大学, 附属病院, 准教授 (80324078)
• Project Period (FY): 2009 – 2011
• Keywords: 遺伝子多型 / 免疫関連遺伝子 / 移植片対宿主病

Research Abstract

When the impact of immune-related gene polymorphisms was examined in patients and their donors of unrelated hematopoietic stem cell transplantation, genetic variations in the NKG2D, Granzyme B, CXCL10, NLRP3, FCGR3A, IL-17, and PTPN22 genes were associated with transplant outcomes. Experimental investigation revealed that the gene polymorphisms of NKG2D, IL-17 and CXCL10 play functionally important roles in the regulation of their production. These findings suggest that determination of such gene polymorphisms prior to transplantation offer clinical benefits in patients undergoing allogeneic hematopoietic stem cell transplantation

Research Products

• [Journal Article] Human microRNA-1245 downregulates the NKG2D receptor in NK cells and impairs NKG2D-mediated functions (2012)
  • Author(s): Espinoza JL, Takami A, (他5名)
  • Journal Title: Haematologica Volume: (in press)
  • DOI: DOI:10.3324/haematol.2011.058529
  • Peer Reviewed
• [Journal Article] Prognostic factors for acute myeloid leukemia patients with t(6 ; 9)(p23 ; q34) who underwent an allogeneic hematopoietic stem cell transplant (2012)
  • Author(s): Ishiyama K, Takami A, (他11名)
  • Journal Title: Leukemia Volume: (in press)
  • DOI: DOI:10.1038/leu.2011.350
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6 ; 9)(p23 ; q34) dramatically improves the patient prognosis : a matched-pair analysis (2012)
  • Author(s): Ishiyama K, Takami A, (他10名)
  • Journal Title: Leukemia Volume: (in press)
  • DOI: DOI:10.1038/leu.2011.229
  • Peer Reviewed
• [Journal Article] A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT (2011)
  • Author(s): Espinoza JL, Takami A, (他13名)
  • Journal Title: Bone Marrow Transplant Volume: 46(11) Pages: 1455-63
  • DOI: DOI:10.1038/bmt.2010.325
  • Peer Reviewed
• [Journal Article] A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation (2011)
  • Author(s): Espinoza JL, Takami A, (他9名)
  • Journal Title: PLoS One Volume: 6(10) Pages: e26229
  • DOI: DOI:10.1371/journal.pone.0026229
  • Peer Reviewed
• [Journal Article] Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies (2011)
  • Author(s): Espinoza LJ, Takami A, (他13名)
  • Journal Title: PLoS One Volume: 6(8) Pages: e23827
  • DOI: DOI:10.1371/journal.pone.0023827
  • Peer Reviewed
• [Journal Article] A single-nucleotide polymorphism of the Fcgamma receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies (2011)
  • Author(s): Takami A, (他15名)
  • Journal Title: Bone Marrow Transplant Volume: 46(2) Pages: 238-43
  • DOI: DOI:10.1038/bmt.2010.88
  • Peer Reviewed
• [Journal Article] NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies (2009)
  • Author(s): Espinoza JL, Takami A, (他12名)
  • Journal Title: Haematologica Volume: 94(10) Pages: 1427-34
  • DOI: DOI:10.3324/haematol.2009.008318
  • Peer Reviewed
• [Presentation] Resveratrol Enhances NKG2D-Mediated Cytotoxicity Against Leukemia Cells by Upregulating Both NKG2D Receptor on NK Cells As Well As NKG2D Ligands on Target Cells (2011)
  • Author(s): Espinoza L, Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2011-12-12
• [Presentation] A Single Nucleotide Polymorphism in the NLRP3 Gene Is Associated with Acute Graft-Versus-Host Disease After HLA-Matched Unrelated Bone Marrow Transplantation (2011)
  • Author(s): Takami A, Espinoza L
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2011-12-12
• [Presentation] A Sequence Variation in the Promoter Region of PTPN22 Gene Predicts Relapse After HLA-Fully-Matched Unrelated Bone Marrow Transplantation for Hematologic Malignancies (2011)
  • Author(s): Espinoza L, Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2011-12-11
• [Presentation] Prognostic Factors of Reducing Relapse in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation From Related Donor for Acute Myeloid Leukemia : The Japan Society for Hematopoietic Cell Transplantation(JSHCT) AML Working Group (2011)
  • Author(s): Yano S, Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2011-12-11
• [Presentation] The Association of a Single Nucleotide Polymorphism in the Chemokine CXCL10 Gene with Transplant Outcomes After HLA-Matched Unrelated Bone Marrow Transplantation for Low Risk Hematologic Malignancies (2011)
  • Author(s): Nakata K, Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2011-12-10
• [Presentation] A minor genetic variation in the Granzyme B gene predicts relapse after HLA-fully-matched unrelated bone marrow transplantation for hematologic malignancies (2010)
  • Author(s): Espinoza JL, Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: 国際会議場(米国)
  • Year and Date: 2010-12-06
• [Presentation] Significant Impact of IL-17A Gene Polymorphism On Transplant Outcomes After HLA-Fully-Matched Unrelated Bone Marrow Transplantation (2009)
  • Author(s): Takami A
  • Organizer: 米国血液学会
  • Place of Presentation: コンベンションセンター(米国)
  • Year and Date: 2009-12-07