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2011 Fiscal Year Final Research Report

FcRγchain-dependent signaling in basophils

Research Project

  • PDF
Project/Area Number 21591238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionShinshu University

Principal Investigator

HIDA Shigeaki  信州大学, 医学系研究科, 准教授 (10345762)

Project Period (FY) 2009 – 2011
Keywordsサイトカイン / 好塩基球 / シグナル伝達
Research Abstract

Basophils have recently been recognized as a mediator of type 2 immune responses producing interleukin-4(IL-4) in response to various stimuli including T cell-derived IL-3. However, little information is available for the signaling pathway of IL-3-induced IL-4 production in basophils. In this study, we showed that FcRγ-dependent signaling in basophils was modulated by a variety of factors such as their activation status and negative regulators.

  • Research Products

    (20 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Book (5 results) Remarks (1 results)

  • [Journal Article] IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15^<-/-> mice2011

    • Author(s)
      Yoshizawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S
    • Journal Title

      J. Immunol.

      Volume: 187 Pages: 5162-5169

    • DOI

      DOI:10.4049/jimmunol.1101561

    • Peer Reviewed
  • [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia2011

    • Author(s)
      Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
    • Journal Title

      Cardiovasc Res.

      Volume: 90(2) Pages: 362-372

    • DOI

      DOI:10.1093/cvr/cvq397

    • Peer Reviewed
  • [Journal Article] IFN-γdeficiency worsen Pneumocystis pneumonia with Th17 development in nude mice2009

    • Author(s)
      Hu, T, Takamoto, M, Hida, S, Tagawa, YI, and Sugane, K
    • Journal Title

      Immunol. Lett.

      Volume: 127(1) Pages: 55-59

    • URL

      http://dx.doi.org/10.1016/j.imlet.2009.08.013

    • Peer Reviewed
  • [Presentation] IL-3-induced IL-13 production by Basophils but not mast cells was sensitive to PIR-B mediated inhibitory signals2011

    • Author(s)
      ODA A, SAKAMOTO Y, SANJO H, NOTAKE T, TAKAI T, HIDA S, TAKI S
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
  • [Presentation] IL-15-independent generation of memory-like" innate "CD8^+ T cells in IRF-2 deficient mice2011

    • Author(s)
      NOTAKE T, ODA A, SANJO H, HIDA S, TAKI S
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
  • [Presentation] The role of apoptosis-associated speck like protein containing a CARD(ASC) in antitumor effect of macrophage2011

    • Author(s)
      OKADA N, KITAZAWA M, FUJII C, HIDA S, TANIGUCHI S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
  • [Presentation] A novel tumor-suppressor functions of ASC in fibrosarcoma2011

    • Author(s)
      KITAZAWA M, HIDA S, OKADA N, MATSUMURA T, FUJII C, TAKEOKA M, MIYAGAWA S, TANIGUCHI S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially2010

    • Author(s)
      NOTAKE T, HORISAWA S, ARAKURA F, HIDA S, TAKI S
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      兵庫
    • Year and Date
      2010-08-25
  • [Presentation] Paired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils2010

    • Author(s)
      ODA A, SAKAMOTO Y, TAKAI T, HIDA S, TAKI S
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      兵庫
    • Year and Date
      2010-08-24
  • [Presentation] Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses2010

    • Author(s)
      HIDA S, ODA A, KOSHI I, TAKI S
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      兵庫
    • Year and Date
      2010-08-23
  • [Presentation] The role of IFN-γand IL-17 on Pneumocysite pneumonia in nude mice.2010

    • Author(s)
      TAKAMOTO M, HU T, HIDA S, TAGAYA Y, SUGANE K
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      兵庫
    • Year and Date
      2010-08-23
  • [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially2009

    • Author(s)
      NOTAKE T, HIDA S, TAKI S
    • Organizer
      第39回日本免疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
  • [Presentation] Basophils" sense" protease allergens with their FcRγ-associated cell surface molecule(s) to produce IL-42009

    • Author(s)
      HIDA S, ODA A, YAMASAKI S, SAITO T, TAKI S
    • Organizer
      第39回日本免疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
  • [Presentation] Pired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent mannar in murine basophils2009

    • Author(s)
      SAKAMOTO Y, ODA A, TAKAI Y, HIDA S, TAKI S
    • Organizer
      第39回日本免疫学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
  • [Book] 「Th2分化と好塩基球.」実験医学2010

    • Author(s)
      肥田重明、瀧伸介
    • Total Pages
      1879-1884
    • Publisher
      羊土社
  • [Book] 「好塩基球からのIL-4産生誘導機序.」炎症と免疫2010

    • Author(s)
      肥田重明、瀧伸介
    • Total Pages
      9-13
    • Publisher
      先端医学社
  • [Book] 「好塩基球のIL-3受容体に会合するFcRγ鎖の機能.」感染炎症免疫2009

    • Author(s)
      肥田重明、瀧伸介
    • Total Pages
      347-349
    • Publisher
      医薬の門社
  • [Book] 「好塩基球のIL-4産生における細胞内シグナル伝達機構.」実験医学2009

    • Author(s)
      瀧伸介、肥田重明
    • Total Pages
      3271-3278
    • Publisher
      羊土社
  • [Book] 「IL-3レセプターシグナルによる好塩基球のサイトカイン産生制御の解明.」医学のあゆみ2009

    • Author(s)
      肥田重明、瀧伸介
    • Total Pages
      303-304
    • Publisher
      医歯薬出版
  • [Remarks]

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-bunshishuyo/index.html

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Published: 2013-07-31  

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