2011 Fiscal Year Final Research Report
Establishment of safety of HLA-haploidentical stem cell transplantation
| Project/Area Number |
21591252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI Hiroya 兵庫医科大学, 医学部, 講師 (70416254)
IKEGAME Kazuhiro 兵庫医科大学, 医学部, 講師 (20372609)
FUJIOKA Tatsuya 兵庫医科大学, 医学部, 助教 (70403045)
YOSHIHARA Satoshi 兵庫医科大学, 医学部, 助教 (90461037)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 造血幹細胞移植 / HLA不適合移植 / 移植片対宿主病 |
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| Research Abstract |
A prospective, multiinstitutional study for HLA-haploidentical reduced-intensity stem cell transplantation was performed, and all recipients achieved donor type engraftment in the phase I study. To treat steroid-resistant graft-versus-host disease(GVHD), we developed a novel therapy, "graft-versus-GVHD", in which patients with severe GVHD underwent re-transplantation using a graft from second donor. Furthermore, we established a murine model of MHC-haploidentical transplantation, in which recipients did not develop severe GVHD when receiving lower intensity of conditioning treatment. We found that host regulatory T cells were involved in the regulation of GVHD.
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Research Products
(31 results)
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[Presentation] Unmanipulated HLA-haploidentical(2-3 antigen-mismatched) stem cell transplantation using myeliablative or reduced-intensity preconditioning regimen2011
Author(s)
Kaida K, Ikegame K, Yoshihara S, Taniguchi K, Ishii S, Kato R, Inoue T, Okada M, Tamaki H, Fujioka T, Soma T, Ogawa H.
Organizer
The 53th annual meeting of the American Society of Hematology
Place of Presentation
San Diego, USA
Year and Date
20111210-13
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